Tag Archives: Wharton’s Jelly

Nova Cells Institute on the air! (Blog Talk Radio)

OLYMPUS DIGITAL CAMERAblog-talk-radioOn Wednesday, 1-18-2017 Nova Cell’s (NCIM) patient educator & care coordinator, Grace Odgers, PhD cand., was interviewed by Denise Messenger on Blog Talk Radio concerning NCIMs unique stem cell medicine program. You can access an audio of this 42m31s minute interview by clicking the link below.

//percolate.blogtalkradio.com/offsiteplayer?hostId=544015&episodeId=9755363

Wharton’s Jelly Stem Cells: safety & more

stem cells from poweredtemplatesADVANTAGES OF WHARTON’S JELLY STEM CELLS ESPECIALLY MESENCYMALS (Designated as WJ-MSC for convenience below) ESPECIALLY WITH RESPECT TO SAFETY

WJ HAS MORE STEM CELLS THAN EITHER BONE MARROW OR ADIPOSE TISSUE

The quantity of mesenchymal stem cells which can typically be obtained from bone marrow is far less than that Wharton’s Jelly: 0.001 to 0.01% mononuclear cells from BM, with 1 g of adipose tissue yielding ~ 5 × 103 stem cells, and Wharton’s jelly 1 to 5 × 104 cells/cm of umbilical cord. In side-by-side comparison studies of MSC from bone marrow adipose tissue and Wharton’s jelly, WJ-MSCs had the highest proliferative capacity.

WJ STEM CELLS ARE MORE PRIMITIVE THAN OTHER ADULT STEM CELL TYPES YET DO NOT PRODUCE TUMORS AND ACTUALLY HAVE ANTI-TUMOR EFFECTS IN VITRO (Lab dish) AND IN VIVO (In living animals & humans)  

WJ-MSC differ from other adult MSCs with respect to the fact they demonstrate far more primitive characteristics e.g., they express embryonic-like stem cell markers including  pluripotency genes, Oct-4, Nanog, and SOX-2 but at levels well below that of embryonic stem (ESC) cells. Despite this, WJ-MSCs do not form tumors (teratomas). This is attributed to the fact that WJ-MS’s have a lower expression of pluripotency genes than embryonic stem cells (ESCs being very pluripotent and by virtue of this are prone to develop teratomas when injected into animals or humans). When WJ-MSCs were injected in immunocompromised and immunodeficient animals they still failed to form tumors.

Also: WJ-MSCs express low levels of the embryonic stem cell pluripotency markers POUF1, NANOG, SOX2 and LIN28, which also plays a role in the fact they do not produce teratomas. WJ-MSCs also synthesize and express several cytokines including IL12A which is associated with the induction of apoptosis (programmed cell death) which is believed to underlie their ability to lyse (eradicate) tumor cells.

Furthermore, the transcriptome of WJ-MSC and ESC differs substantially in that WJ-MSCs demonstrate high expression levels of several tumor suppressor genes and suppresses tumors both in vitro and in vivo. Moreover, large quantities of tumor growth inhibiting cytokines and growth factors are secreted by WJ-MSCs. Also, WJ-MSC cell lysates as well as the conditioned medium they are cultured in strongly inhibited the growth of breast adenocarcinoma, ovarian carcinoma, osteosarcoma, benign neoplastic keloid cells, bladder tumor, and lymphoma cells  in vitro. When WJ-MSC cell lysates and conditioned medium were injected into mammary carcinoma, osteosarcoma, and pancreatic and lung tumors it inhibited their growth and shrank the tumors in vivo .

WJ-MSCs DO NOT CAUSE IMMUNE REJECTION OR ADVERSE REACTIONS  

WJ-MSCs have also been found to be immunoprivileged which is to say they escape rejection or adverse immune reactions. Part of the reason for this lies in the fact WJ-MSCs have low MHC-I levels and an absence of MHC-II expression. And, though they synthesize low amounts of MHC class I, WJ-MSCs have no immunogenicity. Research indicates that this is due to the fact they  do not express costimulatory molecules such as CD 40, CD80, CD86, and also produce high levels of immune response inhibitors such as indoleamine-2,3-dioxygenase (IDO), prostaglandin E2 (PGE2) and leukocyte antigen G6 (HLA-G6).

NOVA CELLS INSTITUTE HARVESTS & MAKES CLINICAL USE OF STEM CELLS ISOLATED FROM (UMBILICAL CORD) WHARTON’S JELLY CELLS: https://ncimx.wordpress.com/2015/03/15/whartons-jelly-stem-cells/

ADDITIONAL REFERENCES – NIH PubMed results (5-1-2016)

Wharton’s Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model.
Xie ZH, Liu Z, Zhang XR, Yang H, Wei LF, Wang Y, Xu SL, Sun L, Lai C, Bi JZ, Wang XY.
Clin Exp Med. 2016 Feb;16(1):89-98. doi: 10.1007/s10238-015-0375-0. Epub 2015 Jul 19.
PMID: 26188488 [PubMed – in process]
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Therapeutic influence of intraperitoneal injection of Wharton’s jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis.
Luo HJ, Xiao XM, Zhou J, Wei W.
Genet Mol Res. 2015 Apr 17;14(2):3606-17. doi: 10.4238/2015.April.17.10.
PMID: 25966129 [PubMed – indexed for MEDLINE] Free Article
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Effect of human Wharton’s jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of lung cancer cells.
Hendijani F, Javanmard ShH, Rafiee L, Sadeghi-Aliabadi H.
Res Pharm Sci. 2015 Mar-Apr;10(2):134-42.
PMID: 26487890 [PubMed] Free PMC Article
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Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.
Carlsson PO, Schwarcz E, Korsgren O, Le Blanc K.
Diabetes. 2015 Feb;64(2):587-92. doi: 10.2337/db14-0656. Epub 2014 Sep 9.
PMID: 25204974 [PubMed – indexed for MEDLINE] Free Article
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. The Potential of Wharton’s Jelly Derived Mesenchymal Stem Cells in Treating Patients with Cystic Fibrosis.
Boruczkowski D, Gładysz D, Demkow U, Pawelec K.
Adv Exp Med Biol. 2015;833:23-9. doi: 10.1007/5584_2014_17. Review.
PMID: 25248343 [PubMed – indexed for MEDLINE]
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Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance.
Kalaszczynska I, Ferdyn K.
Biomed Res Int. 2015;2015:430847. doi: 10.1155/2015/430847. Epub 2015 Mar 15. Review.
PMID: 25861624 [PubMed – indexed for MEDLINE] Free PMC Article
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Undifferentiated Wharton’s Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice.
Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF.
Cell Transplant. 2015;24(8):1555-70. doi: 10.3727/096368914X683016. Epub 2014 Jul 15.
PMID: 25198179 [PubMed – in process]
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Effects of Wharton’s jelly-derived mesenchymal stem cells on neonatal neutrophils.
Khan I, Zhang L, Mohammed M, Archer FE, Abukharmah J, Yuan Z, Rizvi SS, Melek MG, Rabson AB, Shi Y, Weinberger B, Vetrano AM.
J Inflamm Res. 2014 Dec 31;8:1-8. doi: 10.2147/JIR.S71987. eCollection 2015.
PMID: 25678809 [PubMed] Free PMC Article
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A comparison of Wharton’s jelly and cord blood as a source of mesenchymal stem cells for diabetes cell therapy.
El-Demerdash RF, Hammad LN, Kamal MM, El Mesallamy HO.
Regen Med. 2015;10(7):841-55. doi: 10.2217/rme.15.49. Epub 2015 Nov 6.
PMID: 26541176 [PubMed – in process]
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. Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton’s Jelly, Bone Marrow, and Pancreatic Tissues.
Kao SY, Shyu JF, Wang HS, Lin CH, Su CH, Chen TH, Weng ZC, Tsai PJ.
Stem Cells Int. 2015;2015:306158. doi: 10.1155/2015/306158. Epub 2015 Jul 29.
PMID: 26294917 [PubMed] Free PMC Article
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. Roles of the co-culture of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells with rat pancreatic cells in the treatment of rats with diabetes mellitus.
Wang G, Li Y, Wang Y, Dong Y, Wang FS, Ding Y, Kang Y, Xu X.
Exp Ther Med. 2014 Nov;8(5):1389-1396. Epub 2014 Sep 22.
PMID: 25289028 [PubMed] Free PMC Article
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Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation.
Li X, Bai J, Ji X, Li R, Xuan Y, Wang Y.
Int J Mol Med. 2014 Sep;34(3):695-704. doi: 10.3892/ijmm.2014.1821. Epub 2014 Jun 25.
PMID: 24970492 [PubMed – indexed for MEDLINE] Free PMC Article
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Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy.
Woodworth TG, Furst DE.
Arthritis Res Ther. 2014 Jul 30;16(4):113. doi: 10.1186/ar4677.
PMID: 25166210 [PubMed – indexed for MEDLINE] Free PMC Article
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A preliminary evaluation of efficacy and safety of Wharton’s jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus.
Liu X, Zheng P, Wang X, Dai G, Cheng H, Zhang Z, Hua R, Niu X, Shi J, An Y.
Stem Cell Res Ther. 2014 Apr 23;5(2):57. doi: 10.1186/scrt446.
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Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly.
Amable PR, Teixeira MV, Carias RB, Granjeiro JM, Borojevic R.
Stem Cell Res Ther. 2014 Apr 16;5(2):53. doi: 10.1186/scrt442.
PMID: 24739658 [PubMed – indexed for MEDLINE] Free PMC Article
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Therapeutic effect of transplanted human Wharton’s jelly stem cell-derived oligodendrocyte progenitor cells (hWJ-MSC-derived OPCs) in an animal model of multiple sclerosis.
Mikaeili Agah E, Parivar K, Joghataei MT.
Mol Neurobiol. 2014 Apr;49(2):625-32. doi: 10.1007/s12035-013-8543-2. Epub 2013 Aug 28.
PMID: 23982748 [PubMed – indexed for MEDLINE]
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Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1.
Zou X, Zhang G, Cheng Z, Yin D, Du T, Ju G, Miao S, Liu G, Lu M, Zhu Y.
Stem Cell Res Ther. 2014 Mar 19;5(2):40. doi: 10.1186/scrt428.
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. Effect of combined therapy of human Wharton’s jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.
Hu J, Wang F, Sun R, Wang Z, Yu X, Wang L, Gao H, Zhao W, Yan S, Wang Y.
Endocrine. 2014 Mar;45(2):279-87. doi: 10.1007/s12020-013-9984-0. Epub 2013 May 18.
PMID: 23686639 [PubMed – indexed for MEDLINE]
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Effect of human Wharton’s jelly mesenchymal stem cell paracrine signaling on keloid fibroblasts.
Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Jeschke MG.
Stem Cells Transl Med. 2014 Mar;3(3):299-307. doi: 10.5966/sctm.2013-0120. Epub 2014 Jan 16.
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Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling.
Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Tien CH, Jeschke MG.
Stem Cell Res Ther. 2014 Feb 24;5(1):28. doi: 10.1186/scrt417.
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. Characterization of hepatic markers in human Wharton’s Jelly-derived mesenchymal stem cells.
Buyl K, De Kock J, Najar M, Lagneaux L, Branson S, Rogiers V, Vanhaecke T.
Toxicol In Vitro. 2014 Feb;28(1):113-9. doi: 10.1016/j.tiv.2013.06.014. Epub 2013 Jun 29.
PMID: 23820183 [PubMed – indexed for MEDLINE]
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Human Wharton’s Jelly Mesenchymal Stem Cells plasticity augments scar-free skin wound healing with hair growth.
Sabapathy V, Sundaram B, V M S, Mankuzhy P, Kumar S.
PLoS One. 2014 Apr 15;9(4):e93726. doi: 10.1371/journal.pone.0093726. eCollection 2014.
PMID: 24736473 [PubMed – indexed for MEDLINE] Free PMC Article
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Stem cells from umbilical cord Wharton’s jelly from preterm birth have neuroglial differentiation potential.
Messerli M, Wagner A, Sager R, Mueller M, Baumann M, Surbek DV, Schoeberlein A.
Reprod Sci. 2013 Dec;20(12):1455-64. doi: 10.1177/1933719113488443. Epub 2013 May 13.
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Wharton’s jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction.
Zhang W, Liu XC, Yang L, Zhu DL, Zhang YD, Chen Y, Zhang HY.
Coron Artery Dis. 2013 Nov;24(7):549-58. doi: 10.1097/MCA.0b013e3283640f00.
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Reduction of fibrosis in dibutyltin dichloride-induced chronic pancreatitis using rat umbilical mesenchymal stem cells from Wharton’s jelly.
Zhou CH, Li ML, Qin AL, Lv SX, Wen-Tang, Zhu XY, Li LY, Dong Y, Hu CY, Hu DM, Wang SF.
Pancreas. 2013 Nov;42(8):1291-302. doi: 10.1097/MPA.0b013e318296924e.
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Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells.
Du T, Zou X, Cheng J, Wu S, Zhong L, Ju G, Zhu J, Liu G, Zhu Y, Xia S.
Stem Cell Res Ther. 2013 Jun 4;4(3):59. doi: 10.1186/scrt215.
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Higher propensity of Wharton’s jelly derived mesenchymal stromal cells towards neuronal lineage in comparison to those derived from adipose and bone marrow.
Balasubramanian S, Thej C, Venugopal P, Priya N, Zakaria Z, Sundarraj S, Majumdar AS.
Cell Biol Int. 2013 May;37(5):507-15. doi: 10.1002/cbin.10056. Epub 2013 Feb 18.
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Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, Wharton’s jelly and umbilical cord.
Manochantr S, U-pratya Y, Kheolamai P, Rojphisan S, Chayosumrit M, Tantrawatpan C, Supokawej A, Issaragrisil S.
Intern Med J. 2013 Apr;43(4):430-9. doi: 10.1111/imj.12044.
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. Mesenchymal stem cells derived from Wharton’s Jelly of the umbilical cord: biological properties and emerging clinical applications.
Batsali AK, Kastrinaki MC, Papadaki HA, Pontikoglou C.
Curr Stem Cell Res Ther. 2013 Mar;8(2):144-55. Review.
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Proangiogenic features of Wharton’s jelly-derived mesenchymal stromal/stem cells and their ability to form functional vessels.
Choi M, Lee HS, Naidansaren P, Kim HK, O E, Cha JH, Ahn HY, Yang PI, Shin JC, Joe YA.
Int J Biochem Cell Biol. 2013 Mar;45(3):560-70. doi: 10.1016/j.biocel.2012.12.001. Epub 2012 Dec 12.
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Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton’s jelly.
Trivanović D, Kocić J, Mojsilović S, Krstić A, Ilić V, Djordjević IO, Santibanez JF, Jovcić G, Terzić M, Bugarski D.
Srp Arh Celok Lek. 2013 Mar-Apr;141(3-4):178-86.
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Wharton’s jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: a preliminary report.
López Y, Lutjemeier B, Seshareddy K, Trevino EM, Hageman KS, Musch TI, Borgarelli M, Weiss ML.
Curr Stem Cell Res Ther. 2013 Jan;8(1):46-59.
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Perspectives of employing mesenchymal stem cells from the Wharton’s jelly of the umbilical cord for peripheral nerve repair.
Ribeiro J, Gartner A, Pereira T, Gomes R, Lopes MA, Gonçalves C, Varejão A, Luís AL, Maurício AC.
Int Rev Neurobiol. 2013;108:79-120. doi: 10.1016/B978-0-12-410499-0.00004-6. Review.
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Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis.
Hsieh JY, Wang HW, Chang SJ, Liao KH, Lee IH, Lin WS, Wu CH, Lin WY, Cheng SM.
PLoS One. 2013 Aug 22;8(8):e72604. doi: 10.1371/journal.pone.0072604. eCollection 2013.
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Comparison of mesenchymal stem cells derived from fat, bone marrow, Wharton’s jelly, and umbilical cord blood for treating spinal cord injuries in dogs.
Ryu HH, Kang BJ, Park SS, Kim Y, Sung GJ, Woo HM, Kim WH, Kweon OK.
J Vet Med Sci. 2012 Dec;74(12):1617-30. Epub 2012 Aug 9.
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Hydrogen peroxide preconditioning enhances the therapeutic efficacy of Wharton’s Jelly mesenchymal stem cells after myocardial infarction.
Zhang J, Chen GH, Wang YW, Zhao J, Duan HF, Liao LM, Zhang XZ, Chen YD, Chen H.
Chin Med J (Engl). 2012 Oct;125(19):3472-8.
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Immune characterization of mesenchymal stem cells in human umbilical cord Wharton’s jelly and derived cartilage cells.
Liu S, Yuan M, Hou K, Zhang L, Zheng X, Zhao B, Sui X, Xu W, Lu S, Guo Q.
Cell Immunol. 2012 Jul-Aug;278(1-2):35-44. doi: 10.1016/j.cellimm.2012.06.010. Epub 2012 Jul 16.
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Human umbilical cord Wharton’s jelly mesenchymal stem cells do not transform to tumor-associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem cells.
Subramanian A, Shu-Uin G, Kae-Siang N, Gauthaman K, Biswas A, Choolani M, Bongso A, Chui-Yee F.
J Cell Biochem. 2012 Jun;113(6):1886-95. doi: 10.1002/jcb.24057.
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Comparison of human amniotic fluid-derived and umbilical cord Wharton’s Jelly-derived mesenchymal stromal cells: Characterization and myocardial differentiation capacity.
Bai J, Hu Y, Wang YR, Liu LF, Chen J, Su SP, Wang Y.
J Geriatr Cardiol. 2012 Jun;9(2):166-71. doi: 10.3724/SP.J.1263.2011.12091.
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Immunosuppressive function of mesenchymal stem cells from human umbilical cord matrix in immune thrombocytopenia patients.
Ma L, Zhou Z, Zhang D, Yang S, Wang J, Xue F, Yang Y, Yang R.
Thromb Haemost. 2012 May;107(5):937-50. doi: 10.1160/TH11-08-0596. Epub 2012 Mar 8.
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Comparison of chemokine and receptor gene expression between Wharton’s jelly and bone marrow-derived mesenchymal stromal cells.
Balasubramanian S, Venugopal P, Sundarraj S, Zakaria Z, Majumdar AS, Ta M.
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Wharton’s Jelly stem cells: future clinical applications.
Taghizadeh RR, Cetrulo KJ, Cetrulo CL.
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Neuronal plasticity of human Wharton’s jelly mesenchymal stromal cells to the dopaminergic cell type compared with human bone marrow mesenchymal stromal cells.
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Wharton’s jelly mesenchymal stem cells as candidates for beta cells regeneration: extending the differentiative and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes.
Anzalone R, Lo Iacono M, Loria T, Di Stefano A, Giannuzzi P, Farina F, La Rocca G.
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Immunomodulatory effect of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells on lymphocytes.
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Stem cell homing = Better clinical outcomes

Stem cell homing makes a big difference in clinical outcomes. Watch this short video to learn more about how Nova Cells pulls this off.  

Nova Cells Institute gets stem cells to target tissues using its Beacon Factor. Learn more by getting our FREE e-book “Heroic Medicine” (Click to download). Read about our successful stem cell treatments for spina bifida, cancer, stroke, dementia, autoimmune diseases, and more. Get your FREE e-book “Heroic Medicine” now!

October is #spinabifidaawareness (Spina Bifida Awareness) month. Nova Cells has a high rate of success with spina bifida.

October is #spinabifidaawareness” (Spina Bifida Awareness) month. If you or someone you love is affected by spina bifida, please read this concerning Nova Cell Institute’s highly successful treatment program for this condition: http://www.novacellsinstitute.com/spina-bifida-stem-cells.html

Arthritis & vertigo turnaround in 85 year old lady from Nevada (USA)

Senior Couple At HomeIn later 2014 eight-five (85) year old Patricia Rodriguez went to Mexico to have her longstanding arthritis treated by Nova Cells Institute. During her one day stay she was given umbilical cord stem cells that had been primed to become cells that fight arthritis and promote healing and joint restoration, along with the Beacon Factor.

Upon her return stateside, the very next day Patricia noticed a surge of energy and strength upon walking. However, week after week   positive things of all kinds began surfacing. Her  daughter, Tina, summarized these for Nova Cells as follows:

She has incredible strength in comparison to what was true before (her treatment). She can walk all over Walmart and then when we went to a mall near her home she walked the entire length of it not once but twice, and was only a little tired when we got back to her house”, although, I was tired too.

Tina added, “She can get up from the rocking chair without my daughter having to pull her up. And she can open a can of soda using a finger that could not bear doing this last year”. This was one month after her treatment.

“Also, …and this is the latest thing,…for 48 years Mom had incredibly bad vertigo if she laid on her right side which did not happen when she laid down on her left side. She often said her vertigo was like having the room spin at one hundred miles per hour. Naturally when she slept she made every effort to sleep on her right side. Then last week she woke up on her right side and was absolutely shocked to find she had no vertigo. It has not returned!”

Four months after her treatment she had no arthritis pain, in her hands and right arm, whatsoever.

“Mom was also always afraid of losing her balance. She never fell, but she felt that she might one day do so. She would instinctively grab the rail to go up the stairs in her home and also in mine, and then slowly, cautiously take one step at  a time. She would hold onto the rail and moving up it by taking one step and at the same time moving her left hand over the right hand. She never would let one hand go until she had the other on the rail.”

“Now 5 months after her stem cell treatment she goes up the 15 stair staircase without holding onto anything.”

Nova Cells Institute Mexico offers free case evaluations which people can take advantage of by going to http://www.novacellsinstitute.com/how-to-submit.html

Call 1-562-916-3410

Email NCInfodesk@gmail.com

Wharton’s Jelly Stem Cells

NOVA CELLS INSTITUTE HARVESTS & MAKES CLINICAL USE OF STEM CELLS ISOLATED FROM (UMBILICAL CORD) stem cells from poweredtemplatesWHARTON’S JELLY. BELOW ARE LINKS  TO A SAMPLING OF PAPERS PUBLISHED ON WJ STEM CELLS: 

Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications

BONE REGENERATION

Bone Regeneration Using Wharton’s Jelly Mesenchymal Stem Cells

CANCER

Human Wharton’s jelly mesenchymal stem cell secretome display antiproliferative effect on leukemia cell line and produce additive cytotoxic effect in combination with doxorubicin

Umbilical cord tissue-derived mesenchymal stem cells induce apoptosis in PC-3 prostate cancer cells through activation of JNK and downregulation of PI3K/AKT signaling

CYSTIC FIBROSIS

The Potential of Wharton’s Jelly Derived Mesenchymal Stem Cells in Treating Patients with Cystic Fibrosis

DIABETES

Wharton’s Jelly Mesenchymal Stem Cells for the Treatment of Type 1 Diabetes

MULTIPLE SCLEROSIS

Therapeutic Effect of Transplanted Human Wharton’s Jelly Stem Cell-Derived Oligodendrocyte Progenitor Cells (hWJ-MSC-derived OPCs) in an Animal Model of Multiple Sclerosis

NEURONAL REPAIR & NEW NERVE CELL FORMATION

The Secretome of Bone Marrow and Wharton Jelly Derived Mesenchymal Stem Cells Induces Differentiation and Neurite Outgrowth in SH-SY5Y Cells

Matrix Cells from Wharton’s Jelly Form Neurons and Glia

Neurotrophic factors from human Wharton’s jelly mesenchymal stem cells induce gliogenesis

Wharton’s jelly derived mesenchymal stromal cells: Biological properties, induction of neuronal phenotype and current applications in neurodegeneration research

Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopaminergic Neurons In Vitro: Potential Therapeutic Application for Parkinsonism

TISSUE REGENERATION

Wharton’s jelly mesenchymal stem cells promote wound healing and tissue regeneration

TRAUMATIC BRAIN INJURY

Wharton’s Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain Injury

 

How Arthur Rechlo regained ground lost to Alzheimer’s cousin

NCIM N SIGN - JULY  2013Lewy Body Dementia is sometimes called “Alzheimer’s cousin”. Like Alzheimer’s it is an incurable brain disease that steadily whittles away most sufferers’ cognitive functions including their ability to focus, sleep well, or walk normally. Those with advanced LBD may have trouble swallowing liquids and solids.

Currently LBD affects about 1.4 million Americans. Both radio and TV personality Casey Kasem and Oscar® winning actor Robin Williams had LBD, and legendary Chicago Blackhawks coach Stan Matika was recently diagnosed with it.

LBD has no cure and the best medicine can presently do is relieve symptoms and alleviate patient suffering. The one thing doctors never see is a person with advanced LBD who can hardly walk or talk begin doing so. This all changed after 76 year old Canadian Arthur Rechlo had an experimental treatment in Mexico.

Click to read all about Arthur’s amazing turnaround.

Nova Cells Institute Makes Lewy Body Dementia Breakthrough!

NCIM L.B.D. BREAKTHROUGH ANNOUNCEMENThttp://www.novacellsinstitute.com/LBD/Nova%20Cells%20Institute%20(NCIM)%20Announces%20Lewy%20Body%20Dementia%20%20%20Breakthrough.pdf

LBD NEWS RELEASE WITH PHOTO - ONLINE PR MEDIA - FEB 2015

2-17-15 news release at http://www.onlineprnews.com/news/554299-1424179477-nova-cells-institute-announces-lewy-body-dementia-breakthrough.html/preview

PR UNDERGROUD RELEASE ON LBD - 2-18-15

2-18-15 news release at http://www.prunderground.com/nova-cells-institute-announces-lewy-body-dementia-breakthrough/0053956

Many “giant steps” for Dani

NCIM N SIGN - JULY  2013Danielle “Dani” Smith was born in September 2006 with spina bifida in which her spinal cord did not completely form and resulted in partial paralysis from the waist down (Myelomeningocele). Since then this brave little girl has had five major operations including one to place her spinal cord back in her body, three brain surgeries, and double eye surgery. She then did two stem cell treatments and has undergone lots of physical therapy. And, during June 2013 she was treated in Mexico by Nova Cells using primed stem cells and its Beacon Factor. This treatment and Dani’s responses are reflected in this news release from October 2013: http://www.24-7pressrelease.com/pdf/2013/10/05/press_release_364003.pdf

Dani has made many gains during the year since that news release was published including, most recently, something captured by her mother in a short video. This clip was inserted in an animated video which can be accessed by going to https://www.youtube.com/watch?v=RUBvyFt0Vm4#t=109 or click the screen image below,

 

 

Facebook video & written update by Kara Underwood on her son, Bryson

Kara Underwood

Walking on the treadmill for the first time in his life! He’s in a harnessing system and only has braces from the knees down! We were told he would NEVER in his lifetime do this! All I have to say to every doctor that said NO and he CAN’T and he NEVER WILL is this…….we serve an awesome mighty God who says my son WILL WALK! He promises healing to all who ask for it as we receive it for our son in the name of Jesus!

Ryan Weber (Anoxic Brain Injury): Improvements began surfacing right after his treatment!

To Grace & All The Nova Cells Family:

Sorry for not getting back to you sooner but it has been crazy busy. Mexico was great, nothing we imagined. The hospital where Ryan received his Stem Cell Treatment was so clean and I have been in many different hospitals here in the United States that was not as clean. We enjoyed the Mexican food as it was so flavorful. It made me sad to leave.

Ryan’s Stem Cell treatment was a great success! We noticed a huge difference in his muscle tone when they brought him back from the O.R. I cried when I first picked Ryan up because it was like holding a different kid. Ryan’s muscle tone is completely relaxed. Ryan has started back up with his outpatient physical therapy, warm water therapy and his massage appointments. His therapist were shocked at the difference in his muscle tone. Ryan has more control over his muscles.

Some of the things Ryan has done since his Stem Cell Treatment that he was not able to do before hand include:

HEAD CONTROL -He holds his head in a neutral position now and freely moves it to the left and right to look around. Before Stem Cells, Ryan would either have it tilted to one side or the other or front or back.

Weber 1

Picture taken the day after Ryan’s treatment at the San Diego Zoo. Look at how his arms are more bend, his legs are bend, head in right position. Ryan is actually sitting on the tusk.

HANDS – Ryan is able to open and close his hands freely. He regained the infant grasp reflex. With this he is able to reach out and grab items. Last night (8/26/14), he reached up and grabbed his Dad’s glasses and the later in the night he reached up and grabbed a handful of my hair. Before Stem Cells, Ryan kept his hands closed in a tight fist.

Weber 2

Picture of Ryan’s hands after his Stem Cell treatment

ARMS – Ryan actually is able to control both his arms equally. He is able to bend both elbows at his choice. Ryan is able to control his arms to reach to get items he wants. He still favors the left arm over the right but he was left handed dominant. Before Stem Cells, Ryan did have minimal control over the left arm and no control over the right arm.

Weber 3

Rick and Ryan at the beach before Ryan’s Stem cell treatment. Look at the stiff straight arms and tight closed fist hands

TRUNK (TORSO) – Ryan is able to sit in upright position on our lap with little help. When Ryan sits his chest and belly are straighter. Before Stem Cells, Ryan sat on our lap and needed a lot of help to stay in upright position and usually was tilted to one side or the other.

LEGS – Ryan legs are able to bend at the knees. He is able to control them better alternating them to walk in his walker and today walked in the pool with very little help by himself without a walker. When Ryan sits on our laps Ryan will bend his knees and sit like any other “scientifically Normal” child. When he lays on the floor he will pick up his legs to reposition them. Before Stem Cells, Ryan legs were mainly in a locked straight position. It was a battle to have him sit on our lap, put him in his car seat or in anything that required him to be in a bend position. He would walk in his walker but his body looked like an “S”.

MENTAL – Ryan is happier; he smiles and laughs more. I credit the Stem Cells as he is not always having to deal with very tight muscle which were probably really sore. When Ryan looks at you, he just smiles like he can actually see us clearly. Before he recognized the important people like his siblings, Grandparents and us as his parents but since his Stem Cell treatment-couple of our friends have talked to Ryan and this time Ryan interacted with them.

Most of Ryan’s improvements have been “small” but when you put all the small pieces together it makes for a huge improvement. It’s the little things that matter. I have to tell you a story about our day before we were picked up to go to Mexico.

We were all around and waiting for the phone call to tell us you were on your way. We were sitting outside at the patio set when I opened my pictures in my Phone to find the Creative Miracle Prayer I wanted to say before Ryan’s Stem Cell treatment. My phone usually opens to the last picture taken but that day when I opened my pictures, I started to cry because it automatically opened to a picture of Rick holding Ryan the day he was born back on 12/17/09 (See below). Rick asked what was wrong and I turned my phone to show him the picture that popped up and his jaw dropped. This is the picture that popped up.

Weber 4

I took that as a sign from above that Ryan would be born again. With all of Ryan’s improvements that is exactly what happened! We cannot thank you all enough for making this miracle happen for Ryan. I will send pictures in another email with little explanations of them. Just wanted to get this email of Ryan’s improvements to you. You may share this with everyone and if they want to follow Ryan his Facebook page is www.facebook.com/littlewarriorryan.

Thank you for giving us our little boy back! Lots of love.

Gina & Rick Weber

Tatyana Kushniryuk shares wonderful news about her son Rowan’s response to treatment (Spina Bifida)

2014-03-19 14.28.35My son Roman was born with Spina Bifida in 2010. He is a L4-L5 level which means he cannot void on his own and does not have bowel control. His legs were very weak and he could not walk independently until he was 2.5 years old. He was able to hold on to a walker and push it slowly but the big change came after stem cells. He received his first stem cell treatment in China, and in Mexico twice since then. The latest change was from Mexico.

We arrived to San Diego a few days before treatment and checked into our hotel downtown. The next few days we spent exploring the city and taking a trip to the San Diego SeaWorld courtesy of Warrior Families Beating Spina Bifida Foundation. Roman really enjoyed that trip because he got to see the sea lions and pet the little sharks. He was not as excited about Shamu as I was.

IMAG0225

The next day we were escorted to Mexico across the border with Grace and Abel Pena. They were really great and picked us up in their car and drove us to the hospital. The staff greeted us as we registered in as patients, signed some papers and answered questions about his blood type etc. I can understand how some people may be cautious signing things and giving consent to doctors in a different country but since I knew Grace and Abel from our previous trip to Mexico, I was at ease.

The doctors and nurses were very accommodating and made sure we were comfortable with our room and the procedure. It was much faster than I remember it the first time. The anesthesiologist and doctors talked about how they would only put him to sleep for a very short time and not keep him under sedation when not necessary. They had performed the spinal taps many times and knew their jobs very well. I felt confident in their care and did not have second thoughts about the procedure. I only wish that Roman cooperated as well as I thought he would. He did not like the taste of versed (the relaxing serum before procedures) so we opted to take him without it to the procedure room. The hospital has the coolest stair case that has a slide like side so they can transport people in a wheelchair up and down the twisty ramps.

During the procedure, Grace and I went to eat at a local place so that I would not be nervous and we hurried back because Roman was not going to be in the procedure very long. After we came back, Roman was not awake yet but was brought in soon after. He did great; there was no pain in his back or the IV. He was a bit freaked out thinking that the procedure was just beginning after looking at his IV. It took a while to convince him that we are all done.

After about half an hour, he began eating everything, and I mean everything he could get his hands on. The Jell-O, the rice, the juice, the fruit cup. We had asked for refills. He was feeling really great; He said “Is this Mexico? I like Mexico”…while he’s eating and watching Netflix on our laptop. (by the way, wifi works there and I would take a laptop with Netflix if you have it.)

We had a great experience and soon after we left back across the border to our hotel room. We stopped on the way while Grace and Able treated us to some local cuisine of ice cream, then sandwiches while walking around the outside mall.

Since the trip we have noticed Roman waking up in the middle of the night saying he feels his butt more and that he has to go pee. One day after about 1.5 months he had a wet diaper. He has never had a wet diaper in 6 years! Since then his recurrent infections suddenly stopped and he has been having more strength in his legs to run and walk without his AFO shoes. I am excited seeing these results they are truly worth it! The peeing is becoming more consistent and we are seeing good results in his muscle strength as well.

I encourage anyone that wants to give their kiddo a chance to improve their life to take a chance and make this trip happen.

Tatyana Kushniryuk

2014-03-19 14.23.29

 

VIDEO UPDATE: Bryson Chailer walking without braces!

Kara Underwood posted this video of her son, Bryson, walking without braces to You Tube on Thursday, 7-24-2014: https://www.youtube.com/watch?v=yIr5DJygq6k&feature=youtu.be

Bryson Chailer has some a long way thanks to faith, therapy and, yes, stem cell medicine! 

If you are not acquainted with Bryson’s story here is a link to an earlier Nova Cells Institute blog entry that contains information, links, photos and more: http://ncimx.wordpress.com/2012/05/06/bryson-chailer-rapid-impressive-improvements-in-child-with-spina-bifida/

Bryson & Kara

Photo of Bryson with his Mum, Kara Underwood, taken during December 2013  

Dryden Corvers parents share their Nova Cells experience

Dreaming for Dryden shared a link.
41 minutes ago – 4 pm CDT on June 4 2014

STEM CELL INFORMATION!!!

I have received SO MANY emails requesting information on the stem cells. I would LOVE to talk to each and every one of you personally (and don’t mind doing so) but I do get extremely busy and that often leaves me very forgetful!

I am posting this and pinning it to the top of the page so it is easily accessible.

NOVA Stem Cells Institute (website below):

Yes, it is in Mexico. NO, it is not scary!! The stem cell treatment was done at the women and children’s hospital in Tijuana. The doctors and nurses were very nice and accommodating. It was pretty much like any other hospital. Private room, TV, etc. I will say, the doctors and staff from NOVA speak English… the nurses at the hospital don’t. Just to give a heads up.

The website for NOVA has tons of information, photos, videos, testimonials, etc. You will be dealing with Grace Odgers for information and such at NOVA. Her email is gracepatients@gmail.com and she will GLADLY answer any questions that you may have. If she can’t she will get it.

Our experience was absolutely wonderful. As concerned parents, we left our hotel in San Diego and agreed that if anything felt off, or if we were uncomfortable, we were leaving. No questions asked. But we never had that moment. The procedure is quick, and we were only in Mexico for 3-4 hours at most.

If you have any other questions, please feel free to contact me. As far as progress, browse through Dryden’s page – everything is updated almost daily.

If you do talk to Grace, be sure to tell them that DRYDEN sent you!

Lots of love and GOOD LUCK!!!!!

http://www.wwltv.com/story/news/2014/09/05/14707334/

See More

Nova Cells Institute Mexico Cancer Stem Cell Therapy Treatments
Nova Cells Institute Mexico Cancer Stem Cell Therapy Treatments, NCIM treatments for Spina Bifida, Multiple…

The “why” that motivates & empowers the NCIM family

 

The doctors, administrators, consultants, researchers & ideas people who are part of the Nova Cells family get up each and every day with a single focus & passion:  To find & create new & better ways to bring about healing & restoration.      

HelpingHand

New video: Alejandra crawls on!

 

May 2014 -new Alejandra video: https://www.facebook.com/photo.php?v=613377255426056

Alejandra’s Mum reports: It has been 8mos since Alejandra’s first stem cell treatment and look how she is crawling today Exciting, can’t wait to see what the next one will do! I must give some credit to The March of Dimes, Conductive Education too…for isolating each leg movement independently from the other.

October 12, 2013 blog entry on Alejandra: http://ncimx.wordpress.com/2013/10/12/2-new-videos-of-little-alejandra-spina-bifida-reveal-impressive-progress/

NOVA CELLS SUN GRAPHIC - JULY 2013

NEW video: Dryden Corvers shows off his physical and motor prowess!

Dryden Colverhttps://www.youtube.com/watch?v=k4x7LdrM3vU&feature=youtu.be

“Dani Smith Walks” – You Tube Video update

NOVA CELLS SUN GRAPHIC - JULY 2013Dani Smith walks – 4-7-2014 You Tube video:  https://www.youtube.com/watch?v=YnOGxz2CCMY&feature=youtu.be

Read about Dani in this NCIM blog entry: http://ncimx.wordpress.com/2013/10/05/ncim-pioneering-science-old-fashioned-caring/

Dryden Corvers (spina bifida) continues to make progress!

Dreaming for Dryden

April 5, 2014

It’s been one year since we started this page and started fundraising for Dryden’s trip to NOVA Cells. One of the best decisions we have ever made. Dryden’s new favorite activity is trying to climb. He was climbing up Sissy’s step stool, climbing up the side of the recliner, just wanting to be higher. We are so thankful to everyone who helped make this happen. And so appreciative to NOVA cells for this opportunity. I hope in time this will become a more available treatment. We are certainly going to try again!

Dreaming for Dryden

April 6 2014

He’s a climbing machine!!

 

Photo: He's a climbing machine!!
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Dreaming for Dryden

April 6, 2014

Crawl baby, crawl!!!!! Dryden is now saying (vocally) puppy, baby, mommy, daddy, cookie, cracker, nanny, pawpaw, papa, sissy… I may be forgetting something here but… He’s all of a sudden bursting with vocabulary.

 

 

 

Photo: Crawl baby, crawl!!!!! Dryden is now saying (vocally) puppy, baby, mommy, daddy, cookie, cracker, nanny, pawpaw, papa, sissy... I may be forgetting something here but... He's all of a sudden bursting with vocabulary. :)

 

 

Dryden Corvers (spina bifida): Quick, exiting response to his Nova Cells treatment! (4 days, 2 videos)

Dryden Colver

Dryden is a cute, charming little boy with spina bifida who received primed stem cells & NCIM’s proprietary Beacon Factor on 3-28-14. The entries below are from Dryden’s Facebook page.  

Dreaming for Dryden

March 28

Whew! Long day. We are back at the hotel!!!
Everything went smoothly and we are already seeing some positive results! His feet definitely have better circulation – they are all punk and warm instead of splotchy and cold!

He has been twitching a LOT in his lower legs/feet. This means the nerves are starting to make some sort of connection to his brain. He even moved his left foot and toes when we asked him to (I’ll get video to you in a bit!)

Also – a funny tidbit – he was sitting in my lap and apparently had gas. Those of you who know Dryden know that’s pretty common. What was funny was that every time he would fart, he would look down, look at me and point to his belly. Ha ha! He’s gaining some sensation somewhere new with that too, I suppose!

CLICK TO WATCH A VIDEO OF DRYDEN TAKEN SHORTLY AFTER HIS NCIM TREATMENT

Dreaming for Dryden

April 1

We got back in tonight and stopped in at Dryden’s great grandparents to say hello. Dryden was on the floor and we were all talking. We looked down and he was on his hands and knees CRAWLING!!!! He only went a little ways, but he was very much so 4 point crawling!!! Then as we were sitting there talking about him, he pulled up onto his knees all by himself on the coffee table! Little dude is getting some strength or making some connections – either way – I’m so happy!!!!

CLICK TO WATCH A VIDEO OF DRYDEN TAKEN SHORTLY AFTER HIS NCIM TREATMENT

 Dreaming for Dryden

April 3

Dryden is just continuing to amaze me.

I forgot to mention the other day when we were at his great grandmas that he tried climbing the stairs! Never even noticed them and he was going up!

This morning in therapy he tried crawling a little bit too – but did something even more amazing. He got to his big cube toy and tried pulling up. Not just to his knee either!! She asked him if he wanted to stand up and he said YES!!!! We helped him get his feet secured and he stood there for a short little time playing! Baby steps!!

First time he has ever WANTED to stand!

CLICK TO WATCH A VIDEO OF DRYDEN TAKEN SHORTLY AFTER HIS NCIM TREATMENT

 Dreaming for Dryden

April 4

Dryden wasn’t quite as excited to stand this afternoon, but we made him anyways!
This is him standing up with NO BRACES on!!!

His PT even said she could feel his muscles in his FEET working when he would stand! His ankles didn’t roll or fall out from under him either!

I can only hope that with therapy he will have increased progress!!

Definitely going to be saving for another stem cell treatment in the future!

See More

The Rikky Foresman saga continues: “Rikky is standing!”

Blazin for Rikky – March 3, 2014

https://www.facebook.com/BlazinforRikky

Rikky is standing!!!

Rikky is standing - March 3 2014

READ MORE ON RIKKY FORESMAN AT http://ncimx.wordpress.com/?s=Foresman 

The Angel Sosa saga continues: 24 days without a tonic seizure and counting!

Angel SosaCHECK OUT THIS EXCITING UPDATE POSTED ON ANGEL SOSA’S FACEBOOK PAGE (3-3-2014) 

Since having done stem cells February 6, angel went 24 days without a Tonic seizure!! Before stem cells he was having them everyday 2-4 a day. It only lasted a couple seconds and recovered great afterwards. And with the cluster of infantile spasms some days it seems like there’s none and other days he will have 1-2 maybe lasting only a couple seconds and before he was having 2-4 clusters a day lasting 6-10 mins everyday!! I have also completely weaned him off zonegran his last dose was February 28. So now he’s only on 2 meds depakote and felbamate.

https://www.facebook.com/angel.sosa.52?fref=ts%20

YOU’LL FIND AN EARLIER ENTRY ON ANGEL AT http://ncimx.wordpress.com/2014/02/16/epilepsy-turnaround-for-an-angel-angel-sosa/

Central sleep apnea episodes fall from 66 per night to 7 in Ryan Neighbors, reports mom (Shelly)

Ryan Neighbors - 1 of 4 - January 2014IN A FEB. 10 2014 EMAIL TO GRACE AT NOVA CELLS INSTITUTE, SHELLY NEIGHBORS SHARED THIS EXCITING NEWS ABOUT HER DAUGHTER RYAN: 

I have so much to tell you and show you!

Ryan is moving her legs on her own CONTROLLED!! We’re not walking – but this is a step in the right direction.

Not only that – but she recently had a sleep study to check on her central sleep apnea. Before stem cells, she was having 66 episodes per night. After we Only had 7! They are thinking about taking her off her oxygen!

We hope to see you all again before this fall. I have videos to send but I’m at the gym. I send them when I get home. We love you and hope all is well.

Xoxo
Shelly Neighbors

CHECK OUT THESE PRIOR BLOG ENTRIES ON RYAN: http://ncimx.wordpress.com/?s=Ryan

Epilepsy turnaround for an angel (Angel Sosa)

Angel Sosa is 4 years old and has not exactly had an easy ride in life. Born to loving parents and a large family he entered this world saddled with lots of neurological  and physical challenges. Among them:  Infantile spasms, a  difficult-to-treat form of childhood-onset epilepsy called Lennox–Gastaut syndrome (LGS) or simply Lennox syndrome, and developmental delays. According to his loving Mum, Monique, he was ““having 10 clusters of 10-11 seizures lasting six (6) minutes each day and was having ten tonic seizures a day sometimes lasting up to 3 minutes without breathing.”

As you might expect little Angel’s early life was spent seeing doctors and therapists and taking drugs to control his epilepsy (Three currently: Felbamate, Valproic acid, and Zonisemide). Naturally, his parents kept an eye on the news and the Web for any medical advances that might offer any hope of remediating their son’s intractable epilepsy and other challenges. With the advent and growth of adult (nonembryonic) stem cell treatment programs outside the US they saw evidence that perhaps some form of stem cell therapy could help their little boy. As they sorted through the various private stem cell medicine operations abroad they came across accounts of the many turnarounds in children effected by Nova Cell’s primed stem cell treatments and intravenous use of its proprietary Beacon Factor. This encouraged Monique to reach out to NCIM patient educator & care facilitator, Grace (Ph.D. candidate), by phone. Grace then walked her through what NCIM doctors and scientists had accomplished and documented in treated patients and then ably tackled all her questions and concerns. Satisfied with what she had learned, the Sosa’s, enrolled their son in the NCIM treatment program and read the patient handbook (This link is to the abridged version of NCIM’s patient handbook. Those who wish to access the full version must register). Later, on the heels of Angel’s approval for treatment by NCIM physicians including a pediatric neurologist, she and her husband booked him for care on 6 February (2014).

When the “big day” arrived for Angel, Grace noted this about the little boy:

While waiting for his treatment Angel was very stiff and somewhat arching backward. His eyes were moving around the room randomly and, though he would look at you if you called his name after a couple of times, he did so only for a split second and it seemed that he saw right through you. His mom had to give him his dose of medications because he was getting a little more stiff and she knew they were wearing off.

Angel SosaAngel was then given primed umbilical cord stem cells and the Beacon Factor. Grace noted this at the time:

About an hour after his stem cell treatment Angel’s mom mentioned to us that both she and his father were impressed with how relaxed Angel is including his normally stiff legs. As the attending physician was checking him in recovery Angel did something amazing: He fixed his gaze on him for about 5 seconds. The doctor was both amazed and incredulous. Then Angel’s father said ‘Oh yea, he already has focused  his gaze on his mom and I.’  Within an hour Angel was already aware of his surroundings and the people around him.

In addition, Angel’s legs which were normally ice cold were now pink and warm and remained so.

After Angel got home and settled in Monique shared this with Grace by phone and later by email:

The Thursday morning of his stem cell treatment he had 3 tonic seizures and then after stem cells no more seizures till late Sunday night he had 2 small quick seizures. All this week he’s only had 3 seizures! And no big seizures at all! No more 6 minute clusters 🙂

In therapy his therapists have noticed improvements already! He feels so much stronger! He is tolerating standing a little more and one of his therapists noticed he was using the muscles on his arm and shoulders. Everyone has noticed that he’s more alert and happy and has more energy! On Tuesday he looked at me and smiled Mind you, he has never smiled for no reason.

Monique added that Angel’s three (3) year old sister was super excited by the fact her brother was following her all over the place with his eyes, something she instinctively regarded as a form of playing with her.

She concluded with this:

Thank you NOVA!!! I’m so excited about seeing more gains with my angel! Thank you Grace and Abel!

The Sosa’s have set up a  Facebook page for Angel which is at https://www.facebook.com/angel.sosa.52?fref=ts. This page contains photos, videos, posts and more.

CHECK OUT THIS EXCITING UPDATE POSTED ON ANGEL SOSA’S FACEBOOK PAGE (3-3-2014):

Since having done stem cells February 6, angel went 24 days without a Tonic seizure!! Before stem cells he was having them everyday 2-4 a day. It only lasted a couple seconds and recovered great afterwards. And with the cluster of infantile spasms some days it seems like there’s none and other days he will have 1-2 maybe lasting only a couple seconds and before he was having 2-4 clusters a day lasting 6-10 mins everyday!! I have also completely weaned him off zonegran his last dose was February 28. So now he’s only on 2 meds depakote and felbamate.

GRACE - CLOSE UPWant to know more about NCIM and its stem cell treatment program for neurologic issues in children and adults? Call NCIM’s US information line at 1-562-916-3410 (10 am to 7 pm Pacific Time, Monday through Friday) or email Grace by e-mail at gracepatients@gmail.com.

Do you believe in miracles? If not, read this!

Little Rikky could not feel anything below his knees but started doing so in the first few hours following his Nova Cells treatment! 

POSTED BY RIKKY’S FOLKS ON THEIR LITTLE BOY’S FACEBOOK PAGE ON 1-8-2014 (Link further down below)

Check it out! Rikky had no feeling below his knees prior to the treatment! This is 30 minutes after he came out of the O.R. and we will see results for 6-8 MONTHS!

If you didn’t believe it before when we said it was going work then watch this!!!

CLICK PHOTO TO WATCH THE VIDEO (RIKKY’S FACEBOOK PAGE)

I just want to scream from the freaking rooftops, I am so full of joy and thankfulness! It  exceded whatever I imagined to happen, just seeing hime moving his left leg is giving me chills over and over and over and over again! AND HIS LEGS ARE LOOSEY GOOSEY!EVEN MORE THAN AFTER THERAPY!!!!!!!!!!!!!!!!!!!!!!!

And posted tonight (1-8-2014) from SEAWORLD in San Diego at around 7 pm Pacific Time:

“FEEL MY LEGS, DAD”. So we are sitting watching the dolphin show and Rikky says this because he has shorts on and it’s a little chilly (we all have shorts on btw). He NEVER felt his lower legs before!

And posted to Rikky’s Facebook page on 1-14-2014:

Blazin for Rikky

Went to Rikky’s PT she is amazed at Rikky’s progress from the stem cells! She says it is unbelievable and she is going to write a letter that says how the stem cells worked so well on Rikky. She has been his PT since he was 2 months old, and she has been a PT for over 30 years. She is quite amazed! This makes me quite joyous because she validates what I have been seeing and I know now that I am not imagining things! This is only ONE WEEK after treatment, we will still have progress for 6 MONTHS!! This is so wonderful! Grace and Abel are angels!!! I am so glad we decided to do this! I hope more people will see this progress with Rikky and get this for their kids too! I highly recommend NOVA CELLS INSTITUTE!!! THEY HAVE CHANGED OUR LIVES!!!!!!

POSTED ON 1-24-2014 ON RIKKY’S FACEBOOK PAGE:

Blazin for Rikky

OK, we seriously just went to ER because I haven’t been able to get a catheter in. The ER dr says he is voiding on his own and does not need to be cathed so call his uro Dr and get the tests done to be sure, but he is completely voiding ON HIS OWN!!!!!!

Check out Rikky’s FACEBOOK page at https://www.facebook.com/BlazinforRikky (Videos, posts, comments & more)

 

                  

Update on Ryan Neighbors by her Mum, Shelly (Includes a link to a recent video of Ryan and 4 photos)

New video of Ryan standing ALMOST all on her own:

https://www.facebook.com/photo.php?v=10202462548192683&l=1269382276310712012

We are starting fundraising again this weekend. and our goal is to be back (to Nova Cells) by this summer/fall

Ryan’s core strength is MIND BLOWING. She’s breathing so much better and eating all sorts of different foods. She is also writing her name and is able to stabilize her  trunk and balance when in a crawling position and when standing. Her legs aren’t doing as much as we hoped, BUT she has gained so much strength in her core and in other places I never even thought of it helping her legs. I know for a fact we wouldn’t be where we are today without your help and the stem cells. Hopefully a 2nd round will do much more.

We love you guys and can’t wait to see you again.

GOD IS GOOD. Love you guys MUCHO!!!!

Shelly Neighbors

AND IN A FEBRURY 10, 2014 EMAIL SHELLY HAD THIS TO SHARE WITH NCIM’S GRACE:

I have so much to tell you and show you!

Ryan is moving her legs on her own CONTROLLED!! We’re not walking – but this is a step in the right direction.

Not only that – but she recently had a sleep study to check on her central sleep apnea.  Before stem cells, she was having 66 episodes per night. After we Only had 7! They are thinking about taking her off her oxygen!

We hope to see you all again before this fall. I have videos to send but I’m at the gym. I send them when I get home. We love you and hope all is well.

Xoxo

Shelly Neighbors

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Honor Tinsley: Little girl with spina bifida gets feeling in parts of her body that were previously “dead”

FROM THE “WALL OF HONOR” FACEBOOK PAGE CREATED &  MAINTAINED BY HONOR TINSLEY’S MUM:
Honor has gained feeling in her right leg in the thigh and hip area its coming and going but she has felt it multiple times when we are tickling her. She has also felt us tickling her toes off and on we are back home now and just thrilled about all the changes she is experiencing. She also is feeling so good and she’s so much stronger it seems her energy level has skyrocketed and you can just tell she isn’t feeling as much pain. It has been so amazing to be able to touch her places she previously didn’t even know existed on her body and watch her look around and cry trying to figure out where it’s coming from. She feels it! It’s a whole new world for her now. It’s scary for me at the same time, I know she has been living with a broken femur and has escaped the reality of that pain now she must continue to live with it yet may feel some of that pain. Its been amazing to see her be so happy and full of energy. I’ve said it before and I’ll keep saying it…. God is soooo good. Thank you all for your support and kind words we are blessed to have such an amazing support system.

https://www.facebook.com/photo.php?fbid=477748105671842&set=a.279573335489321.61900.278496448930343&type=1

2 new videos of little Alejandra (spina bifida) reveal impressive progress!

Nova’s Cells Institute (NCIM) doctors, scientists and other participants in its ever-evolving stem cell medicine program celebrate each and every improvement that surfaces in the people it treats. What follows below are links to 2 videos of little Alejandra which showcase the truly impressive post-treatment progress she has made. These videos were posted to Alejandra’s Facebook page by her Mum whose comments follow the link to each video.

Join NCIM as it celebrates little Alejandra’s ongoing journey to betterment and her recent improvements!

https://www.facebook.com/photo.php?v=508529795910803 (2 minutes, 38 seconds)

Antonella’s comment about this video of her daughter, Alejandra: 1 month post stem cells…I so wish I had a video of what she was doing before stem cells because you would not believe this progress…THANK YOU NOVA CELLS, MEXICO!

https://www.facebook.com/photo.php?v=508520542578395 (1 minute, 7 seconds)

Antonella’s comment about this video of her daughter, Alejandra This is how she is moving now…only 1 week after stem cells…THANK YOU NOVA CELLS, MEXICO! — at March of Dimes Canada.

 

Celebrating “Spina Bifida Awareness Month” with 2 patient success stories

Nova Cells Institute is celebrating “Spina Bifida Awareness Month” (October) with a  news release showcasing Danielle “Dani” Smith & Alejandra Germanese. Join us in honoring these 2 by going to http://www.24-7pressrelease.com/press-release/nova-cells-institute-announces-spina-bifida-advances-364003.php

http://www.24-7pressrelease.com/pdf/2013/10/05/press_release_364003.pdf  – PDF version

Abel at lab cabinet

Quotes from mothers of children treated by Nova Cells


NOVA CELLS - A RIVER OF LIGHT & HEALING with contact & website info - Darker background

Doing the Math: What sets Nova Cells apart from the “rest of the pack”?

Do you wonder what sets NCIM apart from other stem cell medicine operations? We have summarized the major differences in a simple chart which you can access by clicking the image below or by clicking or keying in http://bit.ly/18Sf87t

 

DOING THE MATH

Ryan Neighbors News Release on “The Shine” (Europe’s largest spina bifida charity)

THE SHINE - 9-30-2013On Sunday an NCIM press release on little Ryan Neighbors appeared on 3 PR services (24-7 Press Releases, Fire PR in the UK, and Free Press Release) and in the handful of hours since has created a bit of a positive stir. For one thing, Europe’s largest spina bifida charity picked up on tweets of the press releases and ran them on their main website at http://paper.li/SHINEUKCharity/1319719408. Many parents of children with spina bifida also picked up on the news release as well and one, Kara Underwood, whose son Bryson benefitted from treatment by NCIM, had this to say about Nova Cells on Facebook (Sunday 9-29-2013):

Best place on the planet for all your stem cell needs! They have the most caring team of patient coordinators and doctors around! Love them all to pieces! They are helping so many have a better quality of life! I praise God for Nova Cells Institute! 

Email Kara at karalinunderwood@gmail.com

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Want to know more about NCIM and its stem cell treatment program for spina bifida and other neurological issues? Call NCIM’s US information line at 1-562-916-3410 (10 am to 7 pm Pacific Time, Monday through Friday) or email NCIM patient care facilitator/educator Grace by e-mail at gracepatients@gmail.com.

Nova Cells Healing Touch – Spina Bifida Edition (2013)

Click this link to access the NOVA CELLS HEALING TOUCH newsletter, Spina Bifida Edition: http://ncimx.files.wordpress.com/2013/10/nova-cells-healing-touch.pdf

NOVA CELLS SUN GRAPHIC - JULY 2013

Let’s cut to the quick: Why should you go with NCIM’s stem cell program?

Thousands of people have visited this website as part of “shopping” for a stem cell treatment. Many have chosen to be treated by Nova Cell’s after tallying up what it offers. Here is what they have discovered:

  • Nova Cells Institute of Mexico (NCIM) was founded by doctors, researchers and others who have spent years in the “stem cell industry”, some having been a part of it almost from its beginning.   
  • NCIM’s uses adult not embryonic or fetal stem cells, e.g., stem cells from certifiably disease-free stem cells isolated from umbilical cord blood, placental tissues, and Wharton’s Jelly. It also isolates and uses stem cells from patient’s own bone marrow.      
  • NCIM has developed unique, proprietary technology & lab methods that have made it possible to not only to get stem cells to target tissues, but to prime them to respond to chemical cues by becoming specific cell types that promote repair and healing. No other firm anywhere has this.
  • Treatments are done in modern, secure medical facilities in Mexico (Tijuana).
  • NCIM has developed a powerful treatment for advanced cancer, e.g., treating patients with pooled donor granulocytes, which has gotten many cancer sufferers into partial and complete remission. Its doctors and scientists possess a precise protocol for doing this treatment safely, which no other hospital or clinic anywhere has.
  • NCIM’s stem cell-based treatment has proved especially beneficial in people with cerebral palsy, spina bifida, multiple sclerosis, spinal cord injuries and traumatic brain injuries.
  • NCIM’s contracted medical facilities & labs all enjoy approval by the Mexican equivalent of the FDA.
  • NCIM’s Director of Laboratory Services, Abel Pena, was trained by the head of stem cell research for a major R & D company in southern California.
  • The cost of NCIM’s stem cell treatments are typically far less than other private stem cell treatment operations, not only in Mexico but elsewhere in the world.

Your next step? It’s simple, just click this link and then register: http://www.novacellsinstitute.com/register.html (There is no cost or obligation whatsoever)

You can also get more information or ask questions by calling NCIM’s U.S. information line at 1-562-916-3410 or emailing NCIM at NCInfodesk@gmail.com    

NOVA CELLS SUN GRAPHIC - JULY 2013

February 2013 update on Spencer Tomc (spina bifida) by his Mum, Jennifer

Tomc FamilyOn November 13, 2012, we had the privilege of heading back down to Nova Cells Institute in Mexico for another stem cell treatment for our son Spencer.  He has been doing great since the last treatment and we wanted to keep up his progress and see more improvements.  We were excited because this treatment would be new for Spencer in the sense he would be getting stem cell “Beacon (or homing) Factor” which was developed by NCIM’s chief biochemist, Abel Pena.

The day was perfect!  We enjoyed a leisurely breakfast and spent the morning by the pool basking in the sunshine and warmth.  Abel and Grace picked us up at the hotel and it was like being reunited with family after more than a year.   We made the trip to Tijuana in record time and got into the hospital where the doctors were waiting for Spencer’s arrival.  Once we checked in, we were settled into our room and Spencer was taken to the OR (Operating Room) for his treatment.  As usual, Abel was in the OR with him which helped him to relax.

Within 30 minutes or less, Spencer came back down and was taken to the recovery room.  The MDs told us the procedure went well and he needed to lay flat for 30 minutes or so.  Spencer was groggy and still wondering when he was going to get his treatment!  We had to explain several times that his treatment was over and that he had received the stem cells.  Within an hour, he was drinking juice and eating small bites of food (mostly Jell-O to feed the stem cells with some sugar).  He generously gave his sherbet to his big brother and proceeded to play video games and watch movies.

By 4:30 pm we were able to get him dressed and ready to leave.  Abel and Grace picked us back up and we headed out for dinner at a local restaurant.  Following dinner, we visited a local shopping mall for a bit of Mexican atmosphere and treats, and then headed back across the border into the US.   Everything went so smoothly – we know God was with us the entire time!

Since the procedure, we have seen so many changes in Spencer from growth spurts to more muscles firing.  His legs are better aligned in his hips – specifically, the muscles in the right leg are firing evenly instead of pulling his right leg outward.  He has started to bend his left knee and wiggles his toes more and it is much easier for him to get to his knees and maintain a kneeling position.  He even told me last week that “he is wiggling his toes” when he usually says “my toes are wiggling”.  The changes we see are new and exciting and seem to be happening with each and every passing day.

We thank God for the knowledge and caring hearts He’s given to Abel and Grace Pena and all the people connected with NCIM.  We are also thankful that we’ve been able to take Spencer for two treatments and can’t wait to see what new things he’s going to do tomorrow and the day after!

Multiple Sclerosis: Three recent cases

Mr. J. R. is a 49 year old Mexican national who has been struggling with Progressive Relapsing Multiple Sclerosis for six years, which was rapidly progressing prior to his coming to NCIM (January 2012).

He arrived at NCIM’s treatment facility unable to walk and with his speech so slurred only his family was able to understand him.  He also had difficulty swallowing as well as being unable to move his tongue very well. According to NCIM co-administrator & patient care coordinator, Grace, Mr. J. R.’s arms functioned normally but everything from the waist down plus his tongue and throat did not. He was treated with stem cells derived from three umbilical cords, Wharton’s Jelly and his own bone marrow (primed using Nova Cell’s unique laboratory method) along with NCIM’s proprietary Beacon factor.

Six weeks after his treatment Mr. J. R. was able to be understood even on the phone. He was so amazed and ecstatic with the improvement in his ability to communicate that he could not resist calling people to chat plus family and friends whom he often invited to him home to visit with him.

About three months following his treatment he was walking again, specifically taking a few steps at a time and climbing a few stairs — with assistance.

As of August (2012) Mr. J.R. can walk (slowly) without assistance and can also touch his palate with his tongue. He is hoping to be able to return to NCIM in January 2013 for another treatment.

Ms. Elisa is a 38 year old lady diagnosed with Secondary-Progressive Multiple Sclerosis four years ago. Among the things she has been wrestling with:

  • Poor balance
  • Lots of pain in her legs
  • Rigidity in her hands and one leg
  • Migraines
  • Unable to walk well (Alternates using a walker and wheelchair to get about)
  • Severe depression
  • Poor appetite with corresponding weight loss

Ms. Elisa was treated during December 2011 with primed stem cells from Wharton’s Jelly, cord blood and her own bone marrow, along with NCIM’s proprietary Beacon Factor.  

About two months after her treatment Ms. Elisa noticed her migraine headaches were becoming less frequent. In addition, she was able to balance herself to the point of not being afraid to fall any more though she continues to use her walker to get about. The rigidity in the hand and leg on one side of body has diminished and the other leg is no longer rigid though there is some light twitching which she is managing with tonic water and quinine. Also, Ms. Elisa is eating better, has gained some weight, and though she feels sad she no longer feels controlled by depression (The severe bouts of depression having completely disappeared). She reports seeing no further disease progression.

Mr. M. S., the brother of a prominent Mexican politician, is not a Nova Cell’s patient but instead was treated by his primary care doctor in Mexico using stem cells processed and primed by NCIM. He has been struggling with multiple sclerosis for eight (8) years and complained of severe fatigue, blurred and double vision in one eye, problems with his bladder, constipation, lots of muscle spasticity plus loss of muscle strength.

He was treated in February 2012 and responded so amazingly well his family brought him back to Tijuana in the middle of June to get a booster treatment.

Among the benefits Mr. M.S. has reported:  His spasticity is much better especially following his second treatment, his vision is improving and he is getting more control of his bladder. His family is taking him to physical therapy which has resulted in his gaining some physical strength. Perhaps most impressive of all to Mr. M. S. is the fact that his condition has stopped progressing.  

Mr. M.S. anticipates seeing additional gains in the months to come and has pledged to report any and all changes to Nova Cell’s co-administrator and & patient care coordinator, Grace.

Want to know more about NCIM and its stem cell treatment program for neurologic issues including Multiple Sclerosis? Call NCIM’s US information line at 1-562-916-3410 (10 am to 7 pm Pacific Time, Monday through Friday) or email NCIM patient care facilitator/educator Grace by e-mail at gracepatients@gmail.com.