Category Archives: WHARTON’S JELLY STEM CELLS

Wharton’s Jelly Stem Cells: safety & more

stem cells from poweredtemplatesADVANTAGES OF WHARTON’S JELLY STEM CELLS ESPECIALLY MESENCYMALS (Designated as WJ-MSC for convenience below) ESPECIALLY WITH RESPECT TO SAFETY

WJ HAS MORE STEM CELLS THAN EITHER BONE MARROW OR ADIPOSE TISSUE

The quantity of mesenchymal stem cells which can typically be obtained from bone marrow is far less than that Wharton’s Jelly: 0.001 to 0.01% mononuclear cells from BM, with 1 g of adipose tissue yielding ~ 5 × 103 stem cells, and Wharton’s jelly 1 to 5 × 104 cells/cm of umbilical cord. In side-by-side comparison studies of MSC from bone marrow adipose tissue and Wharton’s jelly, WJ-MSCs had the highest proliferative capacity.

WJ STEM CELLS ARE MORE PRIMITIVE THAN OTHER ADULT STEM CELL TYPES YET DO NOT PRODUCE TUMORS AND ACTUALLY HAVE ANTI-TUMOR EFFECTS IN VITRO (Lab dish) AND IN VIVO (In living animals & humans)  

WJ-MSC differ from other adult MSCs with respect to the fact they demonstrate far more primitive characteristics e.g., they express embryonic-like stem cell markers including  pluripotency genes, Oct-4, Nanog, and SOX-2 but at levels well below that of embryonic stem (ESC) cells. Despite this, WJ-MSCs do not form tumors (teratomas). This is attributed to the fact that WJ-MS’s have a lower expression of pluripotency genes than embryonic stem cells (ESCs being very pluripotent and by virtue of this are prone to develop teratomas when injected into animals or humans). When WJ-MSCs were injected in immunocompromised and immunodeficient animals they still failed to form tumors.

Also: WJ-MSCs express low levels of the embryonic stem cell pluripotency markers POUF1, NANOG, SOX2 and LIN28, which also plays a role in the fact they do not produce teratomas. WJ-MSCs also synthesize and express several cytokines including IL12A which is associated with the induction of apoptosis (programmed cell death) which is believed to underlie their ability to lyse (eradicate) tumor cells.

Furthermore, the transcriptome of WJ-MSC and ESC differs substantially in that WJ-MSCs demonstrate high expression levels of several tumor suppressor genes and suppresses tumors both in vitro and in vivo. Moreover, large quantities of tumor growth inhibiting cytokines and growth factors are secreted by WJ-MSCs. Also, WJ-MSC cell lysates as well as the conditioned medium they are cultured in strongly inhibited the growth of breast adenocarcinoma, ovarian carcinoma, osteosarcoma, benign neoplastic keloid cells, bladder tumor, and lymphoma cells  in vitro. When WJ-MSC cell lysates and conditioned medium were injected into mammary carcinoma, osteosarcoma, and pancreatic and lung tumors it inhibited their growth and shrank the tumors in vivo .

WJ-MSCs DO NOT CAUSE IMMUNE REJECTION OR ADVERSE REACTIONS  

WJ-MSCs have also been found to be immunoprivileged which is to say they escape rejection or adverse immune reactions. Part of the reason for this lies in the fact WJ-MSCs have low MHC-I levels and an absence of MHC-II expression. And, though they synthesize low amounts of MHC class I, WJ-MSCs have no immunogenicity. Research indicates that this is due to the fact they  do not express costimulatory molecules such as CD 40, CD80, CD86, and also produce high levels of immune response inhibitors such as indoleamine-2,3-dioxygenase (IDO), prostaglandin E2 (PGE2) and leukocyte antigen G6 (HLA-G6).

NOVA CELLS INSTITUTE HARVESTS & MAKES CLINICAL USE OF STEM CELLS ISOLATED FROM (UMBILICAL CORD) WHARTON’S JELLY CELLS: https://ncimx.wordpress.com/2015/03/15/whartons-jelly-stem-cells/

ADDITIONAL REFERENCES – NIH PubMed results (5-1-2016)

Wharton’s Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model.
Xie ZH, Liu Z, Zhang XR, Yang H, Wei LF, Wang Y, Xu SL, Sun L, Lai C, Bi JZ, Wang XY.
Clin Exp Med. 2016 Feb;16(1):89-98. doi: 10.1007/s10238-015-0375-0. Epub 2015 Jul 19.
PMID: 26188488 [PubMed – in process]
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Therapeutic influence of intraperitoneal injection of Wharton’s jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis.
Luo HJ, Xiao XM, Zhou J, Wei W.
Genet Mol Res. 2015 Apr 17;14(2):3606-17. doi: 10.4238/2015.April.17.10.
PMID: 25966129 [PubMed – indexed for MEDLINE] Free Article
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Effect of human Wharton’s jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of lung cancer cells.
Hendijani F, Javanmard ShH, Rafiee L, Sadeghi-Aliabadi H.
Res Pharm Sci. 2015 Mar-Apr;10(2):134-42.
PMID: 26487890 [PubMed] Free PMC Article
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Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.
Carlsson PO, Schwarcz E, Korsgren O, Le Blanc K.
Diabetes. 2015 Feb;64(2):587-92. doi: 10.2337/db14-0656. Epub 2014 Sep 9.
PMID: 25204974 [PubMed – indexed for MEDLINE] Free Article
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. The Potential of Wharton’s Jelly Derived Mesenchymal Stem Cells in Treating Patients with Cystic Fibrosis.
Boruczkowski D, Gładysz D, Demkow U, Pawelec K.
Adv Exp Med Biol. 2015;833:23-9. doi: 10.1007/5584_2014_17. Review.
PMID: 25248343 [PubMed – indexed for MEDLINE]
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Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance.
Kalaszczynska I, Ferdyn K.
Biomed Res Int. 2015;2015:430847. doi: 10.1155/2015/430847. Epub 2015 Mar 15. Review.
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Undifferentiated Wharton’s Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice.
Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF.
Cell Transplant. 2015;24(8):1555-70. doi: 10.3727/096368914X683016. Epub 2014 Jul 15.
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Effects of Wharton’s jelly-derived mesenchymal stem cells on neonatal neutrophils.
Khan I, Zhang L, Mohammed M, Archer FE, Abukharmah J, Yuan Z, Rizvi SS, Melek MG, Rabson AB, Shi Y, Weinberger B, Vetrano AM.
J Inflamm Res. 2014 Dec 31;8:1-8. doi: 10.2147/JIR.S71987. eCollection 2015.
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A comparison of Wharton’s jelly and cord blood as a source of mesenchymal stem cells for diabetes cell therapy.
El-Demerdash RF, Hammad LN, Kamal MM, El Mesallamy HO.
Regen Med. 2015;10(7):841-55. doi: 10.2217/rme.15.49. Epub 2015 Nov 6.
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. Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton’s Jelly, Bone Marrow, and Pancreatic Tissues.
Kao SY, Shyu JF, Wang HS, Lin CH, Su CH, Chen TH, Weng ZC, Tsai PJ.
Stem Cells Int. 2015;2015:306158. doi: 10.1155/2015/306158. Epub 2015 Jul 29.
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. Roles of the co-culture of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells with rat pancreatic cells in the treatment of rats with diabetes mellitus.
Wang G, Li Y, Wang Y, Dong Y, Wang FS, Ding Y, Kang Y, Xu X.
Exp Ther Med. 2014 Nov;8(5):1389-1396. Epub 2014 Sep 22.
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Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation.
Li X, Bai J, Ji X, Li R, Xuan Y, Wang Y.
Int J Mol Med. 2014 Sep;34(3):695-704. doi: 10.3892/ijmm.2014.1821. Epub 2014 Jun 25.
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Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy.
Woodworth TG, Furst DE.
Arthritis Res Ther. 2014 Jul 30;16(4):113. doi: 10.1186/ar4677.
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A preliminary evaluation of efficacy and safety of Wharton’s jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus.
Liu X, Zheng P, Wang X, Dai G, Cheng H, Zhang Z, Hua R, Niu X, Shi J, An Y.
Stem Cell Res Ther. 2014 Apr 23;5(2):57. doi: 10.1186/scrt446.
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Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly.
Amable PR, Teixeira MV, Carias RB, Granjeiro JM, Borojevic R.
Stem Cell Res Ther. 2014 Apr 16;5(2):53. doi: 10.1186/scrt442.
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Therapeutic effect of transplanted human Wharton’s jelly stem cell-derived oligodendrocyte progenitor cells (hWJ-MSC-derived OPCs) in an animal model of multiple sclerosis.
Mikaeili Agah E, Parivar K, Joghataei MT.
Mol Neurobiol. 2014 Apr;49(2):625-32. doi: 10.1007/s12035-013-8543-2. Epub 2013 Aug 28.
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Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1.
Zou X, Zhang G, Cheng Z, Yin D, Du T, Ju G, Miao S, Liu G, Lu M, Zhu Y.
Stem Cell Res Ther. 2014 Mar 19;5(2):40. doi: 10.1186/scrt428.
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. Effect of combined therapy of human Wharton’s jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.
Hu J, Wang F, Sun R, Wang Z, Yu X, Wang L, Gao H, Zhao W, Yan S, Wang Y.
Endocrine. 2014 Mar;45(2):279-87. doi: 10.1007/s12020-013-9984-0. Epub 2013 May 18.
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Effect of human Wharton’s jelly mesenchymal stem cell paracrine signaling on keloid fibroblasts.
Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Jeschke MG.
Stem Cells Transl Med. 2014 Mar;3(3):299-307. doi: 10.5966/sctm.2013-0120. Epub 2014 Jan 16.
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Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling.
Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Tien CH, Jeschke MG.
Stem Cell Res Ther. 2014 Feb 24;5(1):28. doi: 10.1186/scrt417.
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. Characterization of hepatic markers in human Wharton’s Jelly-derived mesenchymal stem cells.
Buyl K, De Kock J, Najar M, Lagneaux L, Branson S, Rogiers V, Vanhaecke T.
Toxicol In Vitro. 2014 Feb;28(1):113-9. doi: 10.1016/j.tiv.2013.06.014. Epub 2013 Jun 29.
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Human Wharton’s Jelly Mesenchymal Stem Cells plasticity augments scar-free skin wound healing with hair growth.
Sabapathy V, Sundaram B, V M S, Mankuzhy P, Kumar S.
PLoS One. 2014 Apr 15;9(4):e93726. doi: 10.1371/journal.pone.0093726. eCollection 2014.
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Stem cells from umbilical cord Wharton’s jelly from preterm birth have neuroglial differentiation potential.
Messerli M, Wagner A, Sager R, Mueller M, Baumann M, Surbek DV, Schoeberlein A.
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Wharton’s jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction.
Zhang W, Liu XC, Yang L, Zhu DL, Zhang YD, Chen Y, Zhang HY.
Coron Artery Dis. 2013 Nov;24(7):549-58. doi: 10.1097/MCA.0b013e3283640f00.
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Reduction of fibrosis in dibutyltin dichloride-induced chronic pancreatitis using rat umbilical mesenchymal stem cells from Wharton’s jelly.
Zhou CH, Li ML, Qin AL, Lv SX, Wen-Tang, Zhu XY, Li LY, Dong Y, Hu CY, Hu DM, Wang SF.
Pancreas. 2013 Nov;42(8):1291-302. doi: 10.1097/MPA.0b013e318296924e.
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Du T, Zou X, Cheng J, Wu S, Zhong L, Ju G, Zhu J, Liu G, Zhu Y, Xia S.
Stem Cell Res Ther. 2013 Jun 4;4(3):59. doi: 10.1186/scrt215.
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Higher propensity of Wharton’s jelly derived mesenchymal stromal cells towards neuronal lineage in comparison to those derived from adipose and bone marrow.
Balasubramanian S, Thej C, Venugopal P, Priya N, Zakaria Z, Sundarraj S, Majumdar AS.
Cell Biol Int. 2013 May;37(5):507-15. doi: 10.1002/cbin.10056. Epub 2013 Feb 18.
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Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, Wharton’s jelly and umbilical cord.
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Video: Little boy with spina bifida is now moving the toes on both his feet

Rikky Foresman is a little boy with spina bifida who had his first stem cell treatment with Nova Cells Institute during early 2014. Last month (March 2016) he underwent another treatment with laboratory primed umbilical cord stem cells and NCIM’s unique & proprietary “Beacon Factor”. It has now been less than 3 weeks since Rikky’s treatment, and on March 29 (2016) his father posted a video of the boy moving the toes on both his feet on the family’s “Blazin’ for Rikky” Facebook page at https://www.facebook.com/BlazinforRikky/?fref=nf

It should also be noted that Rikky began feeling temperature changes in his legs and feet the very next day following his treatment (while at the beach).

 FORESMAN video - late March 2016

HD
This link is to past stories on Rikky that have been posted on this website:

Read this before you settle on a stem cell or other treatment or therapy in Mexico or elsewhere

E-MAIL Free MS imageNova Cells Institute (NCIM) often gets emails from people who ask about stem cell and other therapies done elsewhere but which have little chance of turning things around for them. Here are some of these treatments along with comments by NCIM experts:

(1) Subcutaneous injections of stem cells to treat serious neurologic and other health challenges, including cancer. COMMENT: Subcutaneously injected stem cells may stimulate production of nerve growth factor or other compounds, but is an iffy way to stimulate healing or regeneration unless one is treating a problem very close to the injection site. Depending on the target tissue or organ, stem cells given by intravenous, intrathecal or other routes is more likely to have the desired therapeutic effect.

(2)  Nova Cells hears from people who have been told that biochemical signals from injured or diseased tissues will attract infused stem cells. This is true but what they aren’t being told is that these signals fade over time or the injected or infuse stem cells typically do not respond fully to them. COMMENT: Nova Cells director of laboratory services, Dr. Abel Pena, created a nontoxic homing/signal amplification (or “beacon”) compound that stimulates damaged or diseased tissues to send out stronger stem cell attractive signals while simultaneously sensitizing stem cells to recognize and respond to these signals. This compound was dubbed, appropriately enough, the “Beacon Factor” and positively no one has it or anything like it but Nova Cells. You can read more about it by clicking this link.

3) Emails occasionally come in from people saying they have been offered some kind of stem cell or other therapy (for a serious or intractable condition) in Mexico or elsewhere for between $1,000-4,000 USD. COMMENT: The old sayings “If it sounds too good to be true, it is” and “caveat emptor” (Buyer beware) certainly applies here. What NCIM has turned up down through the years (with respect to these “medical blue plate specials”) are instances in which: (a) MDs and others gave patients far fewer cells than claimed. In one particular instance, an office worker in a so-called stem cell clinic reported actually seeing a doctor take a vial labelled as containing 5 million umbilical cord stem cells and placing a small quantity from this into each of ten other vials, then administering these to patients who had paid to get 5 million stem cells each; (b) Patients were given “live cell therapy” (embryonic cells from animals typically lambs) but were told  they were getting human umbilical or other adult stem cells: (c) People with advanced, terminal cancer were given low cost treatments that had worked in lab dish or animal studies but bombed out in well designed & executed studies done in humans.

Doing medicine in Mexico is not cheap contrary to what some people think. Unfortunately, there are unscrupulous doctors and clinics that have come up with “cost cutting measures” (like those above) who do a grave disservice to the patients they purport to help.

Abel at lab cabinetNova Cells is able to offer economically priced care, i.e., typically 30% less than other stem cell medicine operations, because it cut out the “middle men”, e.g., professional marketers and public relations people, and was able to get top flight MDs including surgeons on board who believe profits must take a backseat to getting people well. And, its head of laboratory services, Dr. Abel Pena (photo on right), who was trained (in part) by a leading US stem cell biologist, insists on processing & counting all stem cells himself and then priming or programming them (to become cell types that are more likely to effect healing or restoration in a given patient than unprimed stem cells). Dr. Pena personally handles all aspects of stem cell and Beacon Factor processing so as to insure that everything is done to the highest cGMP (manufacturing) standards and the patient is getting exactly what he or she paid for.

SKY BLUE E-BOOK COVER FOR HEROIC MEDICINENova Cells has assembled information on its stem cell medicine program including stem cell priming and its proprietary Beacon Factor in e-book form titled  “Heroic Medicine” which is free at http://www.novacellsinstitute.com/pdf/Heroic%20Medicine.pdf

Stem cell homing = Better clinical outcomes

Stem cell homing makes a big difference in clinical outcomes. Watch this short video to learn more about how Nova Cells pulls this off.  

Nova Cells Institute gets stem cells to target tissues using its Beacon Factor. Learn more by getting our FREE e-book “Heroic Medicine” (Click to download). Read about our successful stem cell treatments for spina bifida, cancer, stroke, dementia, autoimmune diseases, and more. Get your FREE e-book “Heroic Medicine” now!

You’ve got to get stem cells to their target tissue or organ. No one but Nova Cells has a way to reliably pull this off.

DART BOARD - Free MorguefileIf you ever played the game of darts or used a crossbow you know the goal is to hit your target. In the world of stem cell medicine the same holds true. Virtually all stem cell therapy clinics and hospitals infuse or inject stem cells and count on biochemical signals produced by damaged or diseased tissues to “get the darts” (stem cells) to target. This works in principle, yes, but likely winds up with more stem cells lodged in non-target tissues than in the tissues or organ needing healing or restoration. This diminishes responses and outcomes as you would expect.

SONY DSC

But what if you switch on a homing system in the stem cells and amplify the signals in diseased or damaged tissues or organs? More “darts” or “biologic missiles” (stem cells) will hit their mark!

No stem cell clinic or such anywhere has a biologic “guidance & homing signal amplification system” that helps get stem cells to target. None, that is, but Nova Cells Institute which pulls this off thanks to its proprietary Beacon Factor. You can read more about the Beacon Factor by clicking this link.

You will also find information on the Beacon Factor in Nova Cells Institute’s  just published e-book titled “Heroic Medicine”, which is free for downloading at http://www.novacellsinstitute.com/pdf/Heroic%20Medicine.pdf

A list of conditions Nova Cells Institute has successfully treated

NOVA CELLS INSTITUTE NEWSCAST - August 8, 2015Learn more about each of the disorders below by either following the link, or emailing or placing a call. Nova Cells has successfully treated many other conditions so if you do not see your particular challenge here, just ask us about our experience with it!

ALS (Lou Gehrig’s disease) – Email NCInfodesk@gmail.com for specifics or call 1-562-916-3410

Autism – Email NCInfodesk@gmail.com for specifics or call 1-562-916-3410

Cancer Cancer (End-stage & advanced too): http://www.novacellsinstitute.com/cancer-stem-cell-therapy.html

Cardiovascular: https://ncimx.wordpress.com/category/reversing-blockage-in-blood-vessels/

Cerebral Palsyhttps://ncimx.wordpress.com/?s=Cerebral+Palsy

Chronic Fatigue Syndrome (CFS) – Email NCInfodesk@gmail.com for specifics or call 1-562-916-3410 

Dementia/Lewy Body Dementiahttps://ncimx.wordpress.com/?s=Dementia

Epilepsy/Other Seizure Disordershttps://ncimx.wordpress.com/?s=Seizure

Fibromyalgia – Email NCInfodesk@gmail.com for specifics or call 1-562-916-3410 

Fibrosis – Email NCInfodesk@gmail.com for specifics or call 1-562-916-3410 

Multiple sclerosishttps://ncimx.wordpress.com/?s=multiple+sclerosis

Parkinson’s Disease – See alzheimer’s-dementia

Spina Bifidahttps://ncimx.wordpress.com/?s=Spina+Bifida

Spinal Cord Injury/Paralysishttps://ncimx.wordpress.com/?s=spinal+cord+injury

Strokehttps://ncimx.wordpress.com/category/stroke/

Traumatic Brain Injury – Email NCInfodesk@gmail.com for specifics or call 1-562-916-3410 begin_of_the_skype_highlighting 

Rapid improvements in vision, walking, mood & cognition for boy with cerebral palsy treated by Nova Cells

NCIM N SIGN - JULY 2013Linda’s little boy has cerebral palsy and has vision, cognitive and walking issues. Within a week of getting primed stem cells & the nontoxic Beacon Factor by Nova Cells Institute doctors (August 2015), Linda shared this with NCIM’s Grace Odgers, PhD cand. by email (gracepatients@gmail.com):

As you know, my boy has really been struggling for a long time with walking and now after his treatment he just gets up and does it!  Today he was even trying to run about. Also, I see signs his vision has improved too. On top of all this, his temperament is so much better and he is no longer easily frustrated and his ability to focus & take on challenging tasks has improved. For instance, today at therapy he put objects like circles, triangles and stars into the right sorting container which left the staff totally blown away! My husband took in all these leaps forward which left him almost in a state of disbelief!  I wish all the parents of children with CP would get them into treatment with your program. Warmest regards to both you and Dr. Abel, and do watch your email for more progress updates and video clips too of our boy. Love, Linda.

Grace added:

At the hospital, even before we left to take this family back to their hotel in San Diego, the boy was sitting on the floor, then just folded one of his legs and got right up without help from his mom or anyone present. This so amazed the lady that it left her totally wide mouth open. Then at the hotel the boy did it again but this time took about 4 steps and sat down. The mother was simply awed by what was happening.

OLYMPUS DIGITAL CAMERAWant to know more about NCIM and its pioneering treatment program for cerebral palsy (CP), spina bifida and other neurologic conditions? Then grab your phone and call the NCIM U.S. information line at 1-562-916-3410  or email NCIM patient care facilitator/educator Grace Odgers, Ph.D. cand., by e-mail at gracepatients@gmail.com.