What follows below are 2 emails* sent to Nova Cell Institute’s Grace Odgers, Ph.D. cand., by the mother of Danielle “Dani” Smith, a little girl with spina bifida who has been the subject of 2 prior blog entries on this website:
ADVANTAGES OF WHARTON’S JELLY STEM CELLS ESPECIALLY MESENCYMALS (Designated as WJ-MSC for convenience below) ESPECIALLY WITH RESPECT TO SAFETY
WJ HAS MORE STEM CELLS THAN EITHER BONE MARROW OR ADIPOSE TISSUE
The quantity of mesenchymal stem cells which can typically be obtained from bone marrow is far less than that Wharton’s Jelly: 0.001 to 0.01% mononuclear cells from BM, with 1 g of adipose tissue yielding ~ 5 × 103 stem cells, and Wharton’s jelly 1 to 5 × 104 cells/cm of umbilical cord. In side-by-side comparison studies of MSC from bone marrow adipose tissue and Wharton’s jelly, WJ-MSCs had the highest proliferative capacity.
WJ STEM CELLS ARE MORE PRIMITIVE THAN OTHER ADULT STEM CELL TYPES YET DO NOT PRODUCE TUMORS AND ACTUALLY HAVE ANTI-TUMOR EFFECTS IN VITRO (Lab dish) AND IN VIVO (In living animals & humans)
WJ-MSC differ from other adult MSCs with respect to the fact they demonstrate far more primitive characteristics e.g., they express embryonic-like stem cell markers including pluripotency genes, Oct-4, Nanog, and SOX-2 but at levels well below that of embryonic stem (ESC) cells. Despite this, WJ-MSCs do not form tumors (teratomas). This is attributed to the fact that WJ-MS’s have a lower expression of pluripotency genes than embryonic stem cells (ESCs being very pluripotent and by virtue of this are prone to develop teratomas when injected into animals or humans). When WJ-MSCs were injected in immunocompromised and immunodeficient animals they still failed to form tumors.
Also: WJ-MSCs express low levels of the embryonic stem cell pluripotency markers POUF1, NANOG, SOX2 and LIN28, which also plays a role in the fact they do not produce teratomas. WJ-MSCs also synthesize and express several cytokines including IL12A which is associated with the induction of apoptosis (programmed cell death) which is believed to underlie their ability to lyse (eradicate) tumor cells.
Furthermore, the transcriptome of WJ-MSC and ESC differs substantially in that WJ-MSCs demonstrate high expression levels of several tumor suppressor genes and suppresses tumors both in vitro and in vivo. Moreover, large quantities of tumor growth inhibiting cytokines and growth factors are secreted by WJ-MSCs. Also, WJ-MSC cell lysates as well as the conditioned medium they are cultured in strongly inhibited the growth of breast adenocarcinoma, ovarian carcinoma, osteosarcoma, benign neoplastic keloid cells, bladder tumor, and lymphoma cells in vitro. When WJ-MSC cell lysates and conditioned medium were injected into mammary carcinoma, osteosarcoma, and pancreatic and lung tumors it inhibited their growth and shrank the tumors in vivo .
WJ-MSCs DO NOT CAUSE IMMUNE REJECTION OR ADVERSE REACTIONS
WJ-MSCs have also been found to be immunoprivileged which is to say they escape rejection or adverse immune reactions. Part of the reason for this lies in the fact WJ-MSCs have low MHC-I levels and an absence of MHC-II expression. And, though they synthesize low amounts of MHC class I, WJ-MSCs have no immunogenicity. Research indicates that this is due to the fact they do not express costimulatory molecules such as CD 40, CD80, CD86, and also produce high levels of immune response inhibitors such as indoleamine-2,3-dioxygenase (IDO), prostaglandin E2 (PGE2) and leukocyte antigen G6 (HLA-G6).
NOVA CELLS INSTITUTE HARVESTS & MAKES CLINICAL USE OF STEM CELLS ISOLATED FROM (UMBILICAL CORD) WHARTON’S JELLY CELLS: https://ncimx.wordpress.com/2015/03/15/whartons-jelly-stem-cells/
ADDITIONAL REFERENCES – NIH PubMed results (5-1-2016)
|Wharton’s Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model.|
|Xie ZH, Liu Z, Zhang XR, Yang H, Wei LF, Wang Y, Xu SL, Sun L, Lai C, Bi JZ, Wang XY.|
|Clin Exp Med. 2016 Feb;16(1):89-98. doi: 10.1007/s10238-015-0375-0. Epub 2015 Jul 19.|
|PMID: 26188488 [PubMed – in process]|
|Therapeutic influence of intraperitoneal injection of Wharton’s jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis.|
|Luo HJ, Xiao XM, Zhou J, Wei W.|
|Genet Mol Res. 2015 Apr 17;14(2):3606-17. doi: 10.4238/2015.April.17.10.|
|PMID: 25966129 [PubMed – indexed for MEDLINE] Free Article|
|Effect of human Wharton’s jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of lung cancer cells.|
|Hendijani F, Javanmard ShH, Rafiee L, Sadeghi-Aliabadi H.|
|Res Pharm Sci. 2015 Mar-Apr;10(2):134-42.|
|PMID: 26487890 [PubMed] Free PMC Article|
|Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.|
|Carlsson PO, Schwarcz E, Korsgren O, Le Blanc K.|
|Diabetes. 2015 Feb;64(2):587-92. doi: 10.2337/db14-0656. Epub 2014 Sep 9.|
|PMID: 25204974 [PubMed – indexed for MEDLINE] Free Article|
|.||The Potential of Wharton’s Jelly Derived Mesenchymal Stem Cells in Treating Patients with Cystic Fibrosis.|
|Boruczkowski D, Gładysz D, Demkow U, Pawelec K.|
|Adv Exp Med Biol. 2015;833:23-9. doi: 10.1007/5584_2014_17. Review.|
|PMID: 25248343 [PubMed – indexed for MEDLINE]|
|Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance.|
|Kalaszczynska I, Ferdyn K.|
|Biomed Res Int. 2015;2015:430847. doi: 10.1155/2015/430847. Epub 2015 Mar 15. Review.|
|PMID: 25861624 [PubMed – indexed for MEDLINE] Free PMC Article|
|Undifferentiated Wharton’s Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice.|
|Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF.|
|Cell Transplant. 2015;24(8):1555-70. doi: 10.3727/096368914X683016. Epub 2014 Jul 15.|
|PMID: 25198179 [PubMed – in process]|
|Effects of Wharton’s jelly-derived mesenchymal stem cells on neonatal neutrophils.|
|Khan I, Zhang L, Mohammed M, Archer FE, Abukharmah J, Yuan Z, Rizvi SS, Melek MG, Rabson AB, Shi Y, Weinberger B, Vetrano AM.|
|J Inflamm Res. 2014 Dec 31;8:1-8. doi: 10.2147/JIR.S71987. eCollection 2015.|
|PMID: 25678809 [PubMed] Free PMC Article|
|A comparison of Wharton’s jelly and cord blood as a source of mesenchymal stem cells for diabetes cell therapy.|
|El-Demerdash RF, Hammad LN, Kamal MM, El Mesallamy HO.|
|Regen Med. 2015;10(7):841-55. doi: 10.2217/rme.15.49. Epub 2015 Nov 6.|
|PMID: 26541176 [PubMed – in process]|
|.||Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton’s Jelly, Bone Marrow, and Pancreatic Tissues.|
|Kao SY, Shyu JF, Wang HS, Lin CH, Su CH, Chen TH, Weng ZC, Tsai PJ.|
|Stem Cells Int. 2015;2015:306158. doi: 10.1155/2015/306158. Epub 2015 Jul 29.|
|PMID: 26294917 [PubMed] Free PMC Article|
|.||Roles of the co-culture of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells with rat pancreatic cells in the treatment of rats with diabetes mellitus.|
|Wang G, Li Y, Wang Y, Dong Y, Wang FS, Ding Y, Kang Y, Xu X.|
|Exp Ther Med. 2014 Nov;8(5):1389-1396. Epub 2014 Sep 22.|
|PMID: 25289028 [PubMed] Free PMC Article|
|Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation.|
|Li X, Bai J, Ji X, Li R, Xuan Y, Wang Y.|
|Int J Mol Med. 2014 Sep;34(3):695-704. doi: 10.3892/ijmm.2014.1821. Epub 2014 Jun 25.|
|PMID: 24970492 [PubMed – indexed for MEDLINE] Free PMC Article|
|Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy.|
|Woodworth TG, Furst DE.|
|Arthritis Res Ther. 2014 Jul 30;16(4):113. doi: 10.1186/ar4677.|
|PMID: 25166210 [PubMed – indexed for MEDLINE] Free PMC Article|
|A preliminary evaluation of efficacy and safety of Wharton’s jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus.|
|Liu X, Zheng P, Wang X, Dai G, Cheng H, Zhang Z, Hua R, Niu X, Shi J, An Y.|
|Stem Cell Res Ther. 2014 Apr 23;5(2):57. doi: 10.1186/scrt446.|
|PMID: 24759263 [PubMed – indexed for MEDLINE] Free PMC Article|
|Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly.|
|Amable PR, Teixeira MV, Carias RB, Granjeiro JM, Borojevic R.|
|Stem Cell Res Ther. 2014 Apr 16;5(2):53. doi: 10.1186/scrt442.|
|PMID: 24739658 [PubMed – indexed for MEDLINE] Free PMC Article|
|Therapeutic effect of transplanted human Wharton’s jelly stem cell-derived oligodendrocyte progenitor cells (hWJ-MSC-derived OPCs) in an animal model of multiple sclerosis.|
|Mikaeili Agah E, Parivar K, Joghataei MT.|
|Mol Neurobiol. 2014 Apr;49(2):625-32. doi: 10.1007/s12035-013-8543-2. Epub 2013 Aug 28.|
|PMID: 23982748 [PubMed – indexed for MEDLINE]|
|Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1.|
|Zou X, Zhang G, Cheng Z, Yin D, Du T, Ju G, Miao S, Liu G, Lu M, Zhu Y.|
|Stem Cell Res Ther. 2014 Mar 19;5(2):40. doi: 10.1186/scrt428.|
|PMID: 24646750 [PubMed – indexed for MEDLINE] Free PMC Article|
|.||Effect of combined therapy of human Wharton’s jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.|
|Hu J, Wang F, Sun R, Wang Z, Yu X, Wang L, Gao H, Zhao W, Yan S, Wang Y.|
|Endocrine. 2014 Mar;45(2):279-87. doi: 10.1007/s12020-013-9984-0. Epub 2013 May 18.|
|PMID: 23686639 [PubMed – indexed for MEDLINE]|
|Effect of human Wharton’s jelly mesenchymal stem cell paracrine signaling on keloid fibroblasts.|
|Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Jeschke MG.|
|Stem Cells Transl Med. 2014 Mar;3(3):299-307. doi: 10.5966/sctm.2013-0120. Epub 2014 Jan 16.|
|PMID: 24436441 [PubMed – indexed for MEDLINE] Free PMC Article|
|Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling.|
|Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Tien CH, Jeschke MG.|
|Stem Cell Res Ther. 2014 Feb 24;5(1):28. doi: 10.1186/scrt417.|
|PMID: 24564987 [PubMed – indexed for MEDLINE] Free PMC Article|
|.||Characterization of hepatic markers in human Wharton’s Jelly-derived mesenchymal stem cells.|
|Buyl K, De Kock J, Najar M, Lagneaux L, Branson S, Rogiers V, Vanhaecke T.|
|Toxicol In Vitro. 2014 Feb;28(1):113-9. doi: 10.1016/j.tiv.2013.06.014. Epub 2013 Jun 29.|
|PMID: 23820183 [PubMed – indexed for MEDLINE]|
|Human Wharton’s Jelly Mesenchymal Stem Cells plasticity augments scar-free skin wound healing with hair growth.|
|Sabapathy V, Sundaram B, V M S, Mankuzhy P, Kumar S.|
|PLoS One. 2014 Apr 15;9(4):e93726. doi: 10.1371/journal.pone.0093726. eCollection 2014.|
|PMID: 24736473 [PubMed – indexed for MEDLINE] Free PMC Article|
|Stem cells from umbilical cord Wharton’s jelly from preterm birth have neuroglial differentiation potential.|
|Messerli M, Wagner A, Sager R, Mueller M, Baumann M, Surbek DV, Schoeberlein A.|
|Reprod Sci. 2013 Dec;20(12):1455-64. doi: 10.1177/1933719113488443. Epub 2013 May 13.|
|PMID: 23670950 [PubMed – indexed for MEDLINE] Free PMC Article|
|Wharton’s jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction.|
|Zhang W, Liu XC, Yang L, Zhu DL, Zhang YD, Chen Y, Zhang HY.|
|Coron Artery Dis. 2013 Nov;24(7):549-58. doi: 10.1097/MCA.0b013e3283640f00.|
|PMID: 23892469 [PubMed – indexed for MEDLINE]|
|Reduction of fibrosis in dibutyltin dichloride-induced chronic pancreatitis using rat umbilical mesenchymal stem cells from Wharton’s jelly.|
|Zhou CH, Li ML, Qin AL, Lv SX, Wen-Tang, Zhu XY, Li LY, Dong Y, Hu CY, Hu DM, Wang SF.|
|Pancreas. 2013 Nov;42(8):1291-302. doi: 10.1097/MPA.0b013e318296924e.|
|PMID: 24152954 [PubMed – indexed for MEDLINE]|
|Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells.|
|Du T, Zou X, Cheng J, Wu S, Zhong L, Ju G, Zhu J, Liu G, Zhu Y, Xia S.|
|Stem Cell Res Ther. 2013 Jun 4;4(3):59. doi: 10.1186/scrt215.|
|PMID: 23734757 [PubMed – indexed for MEDLINE] Free PMC Article|
|Higher propensity of Wharton’s jelly derived mesenchymal stromal cells towards neuronal lineage in comparison to those derived from adipose and bone marrow.|
|Balasubramanian S, Thej C, Venugopal P, Priya N, Zakaria Z, Sundarraj S, Majumdar AS.|
|Cell Biol Int. 2013 May;37(5):507-15. doi: 10.1002/cbin.10056. Epub 2013 Feb 18.|
|PMID: 23418097 [PubMed – indexed for MEDLINE]|
|Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, Wharton’s jelly and umbilical cord.|
|Manochantr S, U-pratya Y, Kheolamai P, Rojphisan S, Chayosumrit M, Tantrawatpan C, Supokawej A, Issaragrisil S.|
|Intern Med J. 2013 Apr;43(4):430-9. doi: 10.1111/imj.12044.|
|PMID: 23176558 [PubMed – indexed for MEDLINE]|
|.||Mesenchymal stem cells derived from Wharton’s Jelly of the umbilical cord: biological properties and emerging clinical applications.|
|Batsali AK, Kastrinaki MC, Papadaki HA, Pontikoglou C.|
|Curr Stem Cell Res Ther. 2013 Mar;8(2):144-55. Review.|
|PMID: 23279098 [PubMed – indexed for MEDLINE]|
|Proangiogenic features of Wharton’s jelly-derived mesenchymal stromal/stem cells and their ability to form functional vessels.|
|Choi M, Lee HS, Naidansaren P, Kim HK, O E, Cha JH, Ahn HY, Yang PI, Shin JC, Joe YA.|
|Int J Biochem Cell Biol. 2013 Mar;45(3):560-70. doi: 10.1016/j.biocel.2012.12.001. Epub 2012 Dec 12.|
|PMID: 23246593 [PubMed – indexed for MEDLINE]|
|Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton’s jelly.|
|Trivanović D, Kocić J, Mojsilović S, Krstić A, Ilić V, Djordjević IO, Santibanez JF, Jovcić G, Terzić M, Bugarski D.|
|Srp Arh Celok Lek. 2013 Mar-Apr;141(3-4):178-86.|
|PMID: 23745340 [PubMed – indexed for MEDLINE] Free Article|
|Wharton’s jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: a preliminary report.|
|López Y, Lutjemeier B, Seshareddy K, Trevino EM, Hageman KS, Musch TI, Borgarelli M, Weiss ML.|
|Curr Stem Cell Res Ther. 2013 Jan;8(1):46-59.|
|PMID: 23270633 [PubMed – indexed for MEDLINE]|
|Perspectives of employing mesenchymal stem cells from the Wharton’s jelly of the umbilical cord for peripheral nerve repair.|
|Ribeiro J, Gartner A, Pereira T, Gomes R, Lopes MA, Gonçalves C, Varejão A, Luís AL, Maurício AC.|
|Int Rev Neurobiol. 2013;108:79-120. doi: 10.1016/B978-0-12-410499-0.00004-6. Review.|
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|Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis.|
|Hsieh JY, Wang HW, Chang SJ, Liao KH, Lee IH, Lin WS, Wu CH, Lin WY, Cheng SM.|
|PLoS One. 2013 Aug 22;8(8):e72604. doi: 10.1371/journal.pone.0072604. eCollection 2013.|
|PMID: 23991127 [PubMed – indexed for MEDLINE] Free PMC Article|
|Comparison of mesenchymal stem cells derived from fat, bone marrow, Wharton’s jelly, and umbilical cord blood for treating spinal cord injuries in dogs.|
|Ryu HH, Kang BJ, Park SS, Kim Y, Sung GJ, Woo HM, Kim WH, Kweon OK.|
|J Vet Med Sci. 2012 Dec;74(12):1617-30. Epub 2012 Aug 9.|
|PMID: 22878503 [PubMed – indexed for MEDLINE] Free Article|
|Hydrogen peroxide preconditioning enhances the therapeutic efficacy of Wharton’s Jelly mesenchymal stem cells after myocardial infarction.|
|Zhang J, Chen GH, Wang YW, Zhao J, Duan HF, Liao LM, Zhang XZ, Chen YD, Chen H.|
|Chin Med J (Engl). 2012 Oct;125(19):3472-8.|
|PMID: 23044308 [PubMed – indexed for MEDLINE] Free Article|
|Immune characterization of mesenchymal stem cells in human umbilical cord Wharton’s jelly and derived cartilage cells.|
|Liu S, Yuan M, Hou K, Zhang L, Zheng X, Zhao B, Sui X, Xu W, Lu S, Guo Q.|
|Cell Immunol. 2012 Jul-Aug;278(1-2):35-44. doi: 10.1016/j.cellimm.2012.06.010. Epub 2012 Jul 16.|
|PMID: 23121974 [PubMed – indexed for MEDLINE]|
|Human umbilical cord Wharton’s jelly mesenchymal stem cells do not transform to tumor-associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem cells.|
|Subramanian A, Shu-Uin G, Kae-Siang N, Gauthaman K, Biswas A, Choolani M, Bongso A, Chui-Yee F.|
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|Comparison of human amniotic fluid-derived and umbilical cord Wharton’s Jelly-derived mesenchymal stromal cells: Characterization and myocardial differentiation capacity.|
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Three year old Evie Morgan has spina bifida and a Facebook page devoted to her journey to betterment at https://www.facebook.com/evieswarriors/. She was treated in Mexico by Nova Cells Institute doctors during April (2016) and soon her Mum, Heather, was emailing NCIM patient care coordinator, Grace Odgers PhD cand., a series of positive reports and video clips. Heather also made posts to the aforementioned Facebook page — three of which follow further down below.
On 4-27-16 Heather Morgan sent this email message to NCIM’s Grace Odgers, PhD cand.:
We felt very comfortable in the hospital. The room was very clean and had a private bathroom and sink. The pediatrician, Dr. Sanchez, was amazing and Evie loved her so much. Dr. Sanchez spoke great English and we had no trouble understanding her at all. The nurses were very attentive to whatever it was that Evie needed and Grace was always right there to translate for us if they had questions or we wanted to say something. The procedure was quick and painless. Within 5 minutes of receiving the treatment Evie began moving her toes. In the week and a half since treatment Evie is still able to move her toes on command (prior to treatment Evie only had very little involuntary movement of her toes), she is urinating more on her own and has very increased balance. She is now beginning to walk much longer distances with her canes (before she had a walker). At her next urology appointment we are going to be able to start discussing next steps in seeing how her bladder can fully function without medication. We are very pleased with the results we have seen thus far and can’t wait to see what else Evie is going to do!
This video was taken 2 days after stem cells. Evie is now able to move her toes on command! Before it was completely involuntary movement. Pardon her sassiness at the beginning 😂 Evie also has incredibly improved balance and is able to walk much longer distances with her canes! #evieswarriors
Evie is showing improvements in her bladder function and abilities since yesterday. We aren’t sure if this is going to be a consistent thing but we are definitely watching now. This is nuts.
Sorry for lack of updates. Everything went perfectly and the treatment is now complete. Within minutes Evie was flexing her right ankle when asked and wiggling all 5 toes. Some of the movement is involuntary right now as the cells are being repaired. We will continue to see results for a few months. Thank you all for supporting our girl! #evieswarriors
Rikky Foresman is a little boy with spina bifida who had his first stem cell treatment with Nova Cells Institute during early 2014. Last month (March 2016) he underwent another treatment with laboratory primed umbilical cord stem cells and NCIM’s unique & proprietary “Beacon Factor”. It has now been less than 3 weeks since Rikky’s treatment, and on March 29 (2016) his father posted a video of the boy moving the toes on both his feet on the family’s “Blazin’ for Rikky” Facebook page at https://www.facebook.com/BlazinforRikky/?fref=nf
It should also be noted that Rikky began feeling temperature changes in his legs and feet the very next day following his treatment (while at the beach).
Note by Nova Cell’s patient educator & care facilitator, Grace Odgers, Ph.D. cand., concerning Jane at the time she was picked up for transport to Mexico plus a brief summary of what took place after her Beacon Factor & stem cell treatments:
Jane arrived seated in a wheelchair with both hands and arms shaking, the left more so than the right. I knew from her history that she was no longer able to walk without assistance. Her son and her partner kind of lift and drag her from her wheelchair to other seating. She is incontinent and thus uses adult Pampers. Very thin ones. She came to treatment accompanied by her live-in partner and her son, both of whom are named Paul. She is given to having occasional hallucinations and is not aware of what is going on around her.
Jane was given large doses of the Beacon Factor by IV drip the first day in hospital. At night she asked to be helped to the restroom. Her partner and son helped her though she walked to the bathroom, and was not dragged.
The day after her stem cell infusion by both spinal tap and IV, Jane became more alert and began looking at her partner and son directly and was conversing with them. She didn’t say a whole lot but she was definitely more aware of everything and everyone around her. She even said “What is going on?”
Notes made by Jane’s son Paul and sent to NCIM:
Jan 20, 2016
1 pm PST, drove down from San Diego to TJ by biochemist Dr. Abel Pena and Grace Odgers.
Checked into the hospital
3 pm PST: She ate some soup with lime Jell-O.
4 pm PST: The doctors put in an IV and began a saline drip. Mom took her usual medication.
5 pm PST: The doctor added the first dose of “The Beacon Factor”. We ordered dinner, tuna fish sandwiches, mixed fruit with bananas, mango and apples, some apple juice and water.
Mom seem to perk up while eating a lot, offering food to her partner and I while discussing how good she felt.
Tested her memory several times, which was still spotty, but she seemed concerned that she was “failing”. Noticed that she had her eyes wide open and answered questions quickly, even though sometimes she didn’t make a lot of sense. We both noticed she had more coherent thought processes and conversation.
7 pm PST: Mom took her final medication of the day.
Jan 21, 2016
6:30 am PST: Arrived back at the hospital. Mom was a bit frantic.
Really need an interpreter the whole time.
Changed bedding and dressings.
7:00 am PST: Mom was given her morning meds.
Took Mom to the restroom.
9:00 am PST: Mom seemed much more lucid, looking around. Finally started to fall back to sleep after eating.
Changed bedding again and her dressings.
She slept until 11:30 am
1 pm PST: Anesthesiologist arrived and introduced himself and the fact he would be giving her a local in her back for the spinal puncture stem cell injection procedure.
2pm – 3pm PST: Talked with Mom who sat up on her own a lot, looked around a great deal, though she was still hallucinating and engaged in some nonsensical talk. Observed what was going on, and looked forward to going home. During conversations she started in with “Come here doggie” and “There’s an old woman, really old, scary, staring at me”
Mom’s facial expressions became much more expressive. She was picking her lips and began folding her blankets and fidgeting a lot.
3 pm PST: The MD arrived to check her blood pressure, heart and blood oxygen level.
3:30 pm PST: Still waiting for them to take her in for her infusion.
She’s asking lots of questions and thinking very clearly after all the “Beacon Factor”.
4:00 pm PST: Mom left to go get stem cells.
5:20 pm PST: Mom was returned to the room, still very groggy from the anesthesia but doing well.
6:00 pm PST: Mom exhibited nearly normal behaviors (for her) of obsessing, and mumbling, but without leaning over as she usually did. More eye movement and she was more concerned over recent events.
8:00 pm PST: Final dose of regular medicines for the day, after which she quickly became very groggy and tired.
9:00 pm PST: Returned to hotel room
Friday Jan 22, 2016
Returned home to Missouri after a day of travel.
Noticed several things, including obsessive behavior though not as extreme. Mom could be easily instructed to lean back, and she looked through the pages of magazines without tearing up the pages as she’d done in the past. During changing, she lifted herself up as instructed. Much more focus than before and she kept up conversations on current topics longer than had been true previously.
Click this link to access the NOVA CELLS HEALING TOUCH newsletter, Spina Bifida Edition: http://ncimx.files.wordpress.com/2013/10/nova-cells-healing-touch.pdf
I brought my son, Bryson Chailer, to Mexico during April (2012) for his first stem cell treatment and I just wanted to give you an update. First of all, let me say, Grace and Abel Pena are two of the sweetest, most caring, most hospitable people I have ever met. They are genuine and truly care about their patients and made our experience top notch. The Mexican doctor and his team and the nursing staff were all fantastic as well. We were treated professionally and with love and everything was explained to us so we could understand every single step of the entire process. We couldn’t be more impressed and will send people your way because of our wonderful experience with Nova Cells Institute.
Within 48 hours of his treatment I saw changes in Bryson and want to share these with everyone: I noticed right away that he had more energy, which is almost unimaginable, because he was already a little fire ball anyway, but he was wound for sound after the stem cell implantation! I noticed right away that he slept more soundly that night and was not tossing and turning and having interrupted sleep. He slept this way last night as well. Bryson has a vesicostomy due to bladder issues, reflux into his kidneys, and the catheter not working properly. This is temporary and to give his bladder a rest and time to repair and will be reversed. Since he urinates out of the stoma, his diaper is wet only at the top and I noticed the morning after the stem cells, his diaper was wet from top to bottom, which I think means he had been urinating, not only from the stoma, but from his penis as well. His diaper was just saturated all in the front. I noticed this same thing this morning. He pooped in the middle of the night and had not been given any kind of stool softener or enema, which is usually what we have to do to get him to poop. He pooped this morning without any enema also. His appetite has increased tremendously. He is eating more food and more often.
Also, more recently Bryson has begun having movement in his right foot and toes! He has always had movement in his left foot and toes, but never on his right foot and toes (Bryson’s level of spina bifida is at L1-L5, so he is paralyzed from the waist down). Having movement in his feet and toes is astounding! I don’t think he has any sensory or sensation yet, but he definitely has something going on to have movement. He wiggles his toes when I run my nails down the bottom of his feet. He is actually responding to the Babinski’s reflex test, which makes your toes flex outward when stimulated.
These are just the few things I’ve seen in my son since his treatment by NCIM. I will let you know of any other improvements as they happen.
You can read more on a blog site set up to showcase Bryson’s story and especially his response to his treatment with adult (nonembryonic) stem cells: http://www.stemcellsforbryson.blogspot.com/
FACEBOOK ENTRIES (2012)
Just wanted to share some progress I saw in Bryson last night! I noticed when he was on his tummy, he lifted his right leg off the ground and held it there for quite some time! I was just sitting there watching in amazement! Both of his legs are moving like crazy at night too!
My mom and I were at Alco today letting Bryson pick out a toy and when he rides in the shopping cart, his legs usually just hand down and dangle, but he actually straightened his left leg from the dangling, bended position! Mom and I both just looked at each other and I bent it back down and he lifted it again, and again! One happy momma and one happy Nana! Praise God for taking the stem cells right where they need to be! Bryson continues to make progress every single day!
Such great news to share!!!! Bryson just went to therapy and the therapist says his left leg is definitely moving and extending by using his quads and hamstrings that are firing! Also, his right hip flexsor is firing! God is making the stem cells work quicker than we could ever even imagine! To God be the glory!
Take That Spina Bifida!!!!!
Bryson doing leg lifts. This video was uploaded from an Android phone
Knew I would get a good report from the therapist! It just keeps on getting better! Bryson now has slight firing in his left hip! So, he has active hamstring and quad function in the left leg, now slight firing of the left hip, active firing in the right hip, and movement in both feet and toes! God is so good and thank you Jesus!
Update on Bryson since stem cell treatment! WARNING-may contain too many details and too much information! Lol!
Because Bryson has spina bifida, he has what’s called neurogenic bladder and bowel. This means the nerves don’t get signals to the brain to go potty like everyone else, so he has to take stool softeners and laxatives on a daily basis in order to go potty. He is currently refusing to take his meds and I have tried everything and I was at my wits end, so I’ve just left it in God’s hands for the past several days, and without any medication, he has pooped totally on his own, with no stool softener or laxatives! He also felt stomach pains for the first time ever from having diarrhea, which should not happen to someone who is paralyzed from the waist down! This may not sound exciting to most people, but to a mom of a child with spina bifida, this is huge! Go stem cells go! I’ve never thanked Jesus for poop and a stomach ache before, but you bet I am now!!!!!
I’m one excited momma right now! Bryson just crawled on his hands and knees for the first time! He crawled 4 big steps before his legs gave way! He has never done anything but army crawl, using his arms, with his legs dragging behind him! He actually crawled on on his hands and knees by sitting on his knees and pulling them forward by using his legs! Yay! My God is so good all the time! Thank you Jesus for your continued healing! Go stem cells go!
My little man just crawled on his hands and knees about 6 feet without stopping! Praise God! Can I get a woot woot!
Thanks to God and Nova Cells Institute, Bryson is doing better than ever after his stem cell treatment and he is walking so great in his RGO braces now!
VIDEO: Go Stem Cells Go!!!!
“Bryson’s Story” an 8 minute, 40 second video compilation “showing progress from birth until stem cell treatment in 2012”: http://www.youtube.com/watch?v=JqySzJ7smKA&feature=share
Praying for Mama! God is still the Great Physician and Healer and the bible says that if you are all believing in total healing, and you are all standing in faith together, your Mama will be healed! Something to think about that will make a huge difference in her quality of like is stem cell treatment. Stem cell transplants are doing phenomenal things for so many diseases today and my son, age 3, who has spina bifida and is paralyzed from the waist down, got stem cell treatment 3 months ago and he is already seeing major results! He is moving his toes, crawling on his hands and knees and is walking in braces with a walker now! He is also off all medications as well! God led us down the path of stem cells for our son and He is making sure those stem cells go right where they need to be in his body and my son is being healed more and more every day! Praise God! God bless your entire family and you are all in my prayers, especially Mama 🙂
Bryson is getting so good at walking in braces with his walker! Miss Elsie is just there for added support and barely has to touch his walker now! He’s doing all the work totally on his own! I am so proud of my little man! We were told Bryson would absolutely NEVER do this and look at him go! Praise God! Nova Cells Institute and their stem cells rock!
LATEST VIDEO: http://www.youtube.com/watch?v=3yggQiXU_wA&feature=share
Monday, August 20, 2012 – Rural TV Feature on Bryson and Donation Information!
LATEST ENTRIES ON BRYSON’S BLOG– 2013
Thursday, February 14, 2013
It’s been so long since I’ve posted and figured it was about time to stop my busy life for about 5 mins to give an update! Shame on me for not taking time until now! Let’s see….. Bryson is still continues to make progress after his stem cell treatment last year and he is walking so great in his RGO braces, using his walker. He’s really become quite the pro at it actually! He still has the vesicostomy in place, but we have been noticing that his bladder capacity seems to be increasing, which is great news. He is crawling on all fours these days and is getting so much stronger and is able to do just about anything. He has a wheelchair now for his main means of getting around, but he tells us that when he gets bigger and is grown up that he will not need his wheelchair because he will be able to stand and walk on his own! We love his positive outlook! He tells his legs, “In the name of Jesus, move legs!” He is commanding that mountain to move just like the bible tells us to! We are very excited to announce that we will be taking Bryson back to Nova Cells Institute in Mexico on April 9th for his second stem cell treatment. We can’t wait to see what results this second round of stem cells brings for him. We will most likely take him to an intensive physical therapy program in another state about 4 to 6 months after the treatment this time. The planning is already in full-swing for the 3rd Annual Barrels for Bryson event and it will be held in September of this year. This one will be even bigger and better than the last one! God has blessed us so much in the past year and we see bright things ahead for our future! We give Him thanks, praise, honor and glory for ALL these blessings and for ALL future blessings! Our faith in God’s healing for Bryson is still as strong as ever and we know God has many great things planned for our sweet baby boy. Bryson is growing up to be a mighty man of God and we know that God will see to it that he prospers in everything he does in life. Reports of more progress to come after the treatment in April, so stay tuned!!!!!
Posted by Kara Underwood
Saturday, August 24, 2013
We have been busy, busy, busy this year! Bryson has made progress by leaps and bounds and he actually starts pre-k on Monday. My goodness, where has the time gone? Our lil guy is growing and getting so big and has been crawling like a champ these days, and I don’t mean army crawling like he used to, I mean crawling on all fours, and he stays on his knees most of the time. This is such progress! He has gotten so much stronger and his balance is improving more and more and his core and lower back are getting stronger as well. He cognitive skills are through the roof! He is so very smart! He continues to walk great in his RGO braces and uses the walker like a pro. The 3rd Annual Barrels 4 Bryson event is just around the corner in September and we are praying for a super turnout so we can purchase a much needed piece of exercise equipment for the house. He needs an exercise bike called the RT-300 that uses e-stim (electric muscle stimulators) for his legs to gain some muscle mass. All the weight bearing in the world and all the stem cells in the world won’t do any good if he doesn’t have the muscles in his legs and hips to support his weight, so he needs this therapy equipment desperately. Of course, nothing is covered by any insurance and it’s quite costly. $26,000 to be exact! Yikes! Please be in agreement with us in asking the Lord to supply our financial needs this year. God has blessed us so much and we know he hears our prayers and we thank Him and glorify Him always! Bryson’s bladder seems to be gaining capacity way more with this stem cell treatment and he sometimes even poops all on his own, without having to do the enema. Yay for pee and poop! Oh, the things that excite and impress a mom of a kid with spina bifida! We are so excited to see what God has in store for Bryson throughout his life. We know for a fact God has healed Bryson and continues to show us His healing more and more every day, as He is placing those stem cells right where they need to be in his body for healing and growing nerves. Bryson can totally lift his left leg all the way in the air and he continues to move his toes and feet. He even pulled his right leg so hard when getting a diaper change that he pulled it right out of my hand! He has so many little twitches and movements that he didn’t have before and it’s so exciting to see these changes. We are about to start hippo therapy (horseback riding) in the fall and after the barrel race, he is going to be getting a new type of therapy called the Anat Baniel Method, which the therapist manually manipulates the muscles to try to re-route signals to the brain to make the legs move. This is gonna be an exciting year with more exciting things to come! The ABM, along with the therapy bike should make significant improvements for Bryson and we can’t wait to witness what God has planned for our little trooper! Bryson never ceases to amaze us with his growth and improvement throughout his short life. He is definitely a mover and a shaker and has big plans. God has used Bryson, our family, and our experiences to help and improve the lives of others and we couldn’t be happier that He chose us in this way. We are so very proud of this brave little boy and we are so glad God chose us to be his parents. Bryson has truly made us better people and has changed our lives for the better in every way. I promise I won’t take so long to report Bryson’s progress next time! Maybe I can get a few things done now that the little toot will be in school 3hrs a day! Lol! Until next time, always remember…….All things can be done through Christ who strengthens us! God bless you and love you!
Posted by Kara Underwood
Friday, October 25, 2013
We are so excited about an upcoming event for Bryson that’s about to get underway! A Mane Event Stallion Auction will be held on Nov. 11-23 and all proceeds will go toward a very expensive piece of medical equipment Bryson needs to build the muscles in his legs so he can have the muscular support needed for weight-bearing and walking. There are some AMAZING stallions up for auction and we are floored by the response we have gotten from the stallion owners who have so generously donated them. The GigerMd is a therapy bicycle that combines mild estim for muscle-building and it costs a whopping $26,000! Yikes! Things like stem cell treatments, alternative therapies, therapy equipment, and things of that nature are not covered by insurance, but are so needed for Bryson’s ability to walk in the future. The 3rd Annual Barrels 4 Bryson event was a huge success and we raised enough money for the $16,000 stem cell treatment he needs and we are so very thankful for everyone who donated and everyone who participated and made that event possible. God has blessed Bryson so much with these fundraisers so he can continue to get the things he needs to make his quality of life better and they help him to achieve his dream of walking one day. We serve an awesome God, don’t we? We would like to thank Dr. Wes Williams for his continued support in the Barrels 4 Bryson event and we want to extend a huge thank you to Erin Kemp, Crystal Nichols, my mom, Kathy Russell, and my niece, Kenzi Pogue for putting this new annual event together for Bryson. We would also like to thank Arron Watson, a very talented song-writer and Texas country artist, for taking notice of this event and generously donating a signed guitar for this auction. Also, for the people who have donated other items for people to bid on. We love you guys! It blows us away at the amount of support everyone has shown, and continues to show, Bryson. He WILL WALK and we thank everyone who has been a part of his journey. We would never be able to afford these things for him without the generous donations of everyone involved in these events. God bless all of you and thank you so much from the bottom of our hearts! May God richly bless each of you!
Posted by Kara Underwood
Want to know more about NCIM and its stem cell treatment program for neurologic issues in children and adults? Call NCIM’s US information line at 1-562-916-3410 (10 am to 7 pm Pacific Time, Monday through Friday) or email NCIM patient care facilitator/educator Grace Pena by e-mail at firstname.lastname@example.org.